ATRX Products

Description

ATRX is encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Bioinformatics

Entrez	22589 Mouse 546 Human
Uniprot	AAH02521 Human NP_000480 Human P46100 Human
Product By Gene ID	546
Alternate Names	alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae)homolog) alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S.cerevisiae) alpha thalassemia/mental retardation syndrome X-linked ATP-dependent helicase ATRX ATR2 DNA dependent ATPase and helicase EC 3.6.1 EC 3.6.4.12 helicase 2, X-linked Juberg-Marsidi syndrome MGC2094 MRXHF1 RAD54 homolog RAD54L SFM1 SHS transcriptional regulator ATRX XH2RAD54 X-linked helicase II X-linked nuclear protein XNPZNF-HX Zinc finger helicase Znf-HX

Research Areas for ATRX

Find related products by research area and learn more about each of the different research areas below.

Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair