DMC1 Antibody (1D12/4)

DMC1 (disrupted meiotic cDNA or LIM15) is a meiosis-specific gene that encodes a nuclear protein which is essential for meiotic homologous recombination, specifically in homologous strand assimilation, and MDC1 also participates in formation of synaptonemal complex as well as double-strand breaks repair at recombination hotspots. DMC1 is a member of RecA family and in eukaryotic cells; there are two RecA homologs, RAD51 and DMC1, which promote the search for homologous DNA sequences and DNA strand exchange resulting in the formation of joint molecules. RAD51 acts both in meiotic recombinations as well as during DNA repair in mitotically dividing cells, however, DMC1 is expressed only during meiosis only. DMC1 interacts with the MND1-PSMC3IP heterodimer and with BRCA2. Dmc1-/- mice are infertile due to decreased germ cells, failing to form synaptonemal complexes and arresting at the leptotene or zygotene stage in late meiosis I. In female mice lacking Dmc1, normal oogenesis is aborted in embryos, and germ cells are depleted in the adult ovary. The phenotypes of Dmc1-/- ovaries are similar to clinical characteristics found in women with premature ovarian failure (POF), however, mutations in the coding sequence of DMC1 were shown to not to associate with POF in women.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-181	Applications	Species
Masson, J et al. The meiosis-specific recombinase hDms1 forms ring structures interacts with hRad51. EMBO J. 18:6552-6560. 1999-01-01 [PMID: 10562567] (WB, IP, Human)	WB, IP	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	1 reviewed by: Sumit sandhu	IF	Mouse	06/29/2020	View Summary Application Immunofluorescence Sample Tested Mouse spermatocytes Species Mouse Lot B1 Comments Comments *Low Rating Note: Novus Innovators Program - new species or application used on a primary antibody.

Array NB100-181

• DMC1 Antibodies
• DMC1 Lysate
• DMC1 Proteins