ARID1A Antibody

ARID1A encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain ARID1A genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using NBP1-88932	Applications	Species
Markowska A, Szarszewska M et al. The role of nesfatin and selected molecular factors in various types of endometrial cancer. Ginekol Pol 2019-07-11 [PMID: 31686413] (IF/IHC, Human)	IF/IHC	Human
Markowska A, Szarszewska M et al. Studies on selected molecular factors in endometrial cancers. Adv Clin Exp Med 2018-01-10 [PMID: 30277666] (IF/IHC, Human)	IF/IHC	Human
Abe H, Hayashi A, Kunita A et al. Altered expression of AT-rich interactive domain 1A in hepatocellular carcinoma. Int J Clin Exp Pathol 2015-01-01 [PMID: 26045782] (IF/IHC, Human)	IF/IHC	Human
Uehara Y, Oda K, Ikeda Y et al. Integrated Copy Number and Expression Analysis Identifies Profiles of Whole-Arm Chromosomal Alterations and Subgroups with Favorable Outcome in Ovarian Clear Cell Carcinomas. PLoS One 2015-01-01 [PMID: 26043110] (IF/IHC, Human)	IF/IHC	Human
He F, Li J, Xu J et al. Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinoma. J Exp Clin Cancer Res 2015-05-15 [PMID: 25975202] (IF/IHC, Human)	IF/IHC	Human
Inada R, Sekine S, Taniguchi H et al. ARID1A expression in gastric adenocarcinoma: Clinicopathological significance and correlation with DNA mismatch repair status. World J Gastroenterol 2015-02-21 [PMID: 25717252] (IF/IHC, Human)	IF/IHC	Human
Biter BG, Aird KM, Garipov A et al. Targeting EZH2 methyltransferase activity in ARID1A mutated cancer cells is synthetic lethal. Nat Med 2015-03-01 [PMID: 25686104]
Howat W, Miller J, Gounaris I et al. Application of ARID1A to murine formalin-fixed paraffin embedded tissue using immunohistochemistry. F1000Res 2014-01-01 [PMID: 25653835] (IF/IHC, Mouse)	IF/IHC	Mouse
Wiegand KC, Hennessy BT, Leung S et al. A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation. BMC Cancer 2014-02-22 [PMID: 24559118]
Wu RC, Ayhan A, Maeda D et al. Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynecologic malignancies. J Pathol 2014-03-01 [PMID: 24338723] (IF/IHC, Human)	IF/IHC	Human
Hsien-Neng Huang, Ming-Chieh Lin, Wen-Chih Huang et al. Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma. Modern Pathology 2015-01-01 [PMID: 24336158] (IF/IHC, Human)	IF/IHC	Human
Mao TL, Ardighieri L, Ayhan A et al. Loss of ARID1A Expression Correlates with Stages of Tumor Progression in Uterine Endometrioid Carcinoma. Am J Surg Pathol 2013-09-01 [PMID: 24076775] (IF/IHC)	IF/IHC
Streppel M, Lata S, DelaBastide M et al. Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barretts esophagus. Oncogene 2014-01-16 [PMID: 23318448]
Guan B, Gao M, Wu CH et al. Functional Analysis of In-frame Indel ARID1A Mutations Reveals New Regulatory Mechanisms of Its Tumor Suppressor Functions. Neoplasia 2012-10-01 [PMID: 23097632]
Xiao W, Awadallah A, Xin W. Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma. Int J Clin Exp Pathol 2012-01-01 [PMID: 22977660] (IF/IHC, Human)	IF/IHC	Human
Ayhan A, Mao TL, Seckin T et al. Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma. Int J Gynecol Cancer 2012-10-01 [PMID: 22976498]
Wu CH, Mao TL, Vang R et al. Endocervical-type Mucinous Borderline Tumors are Related to Endometrioid Tumors Based on Mutation and Loss of Expression of ARID1A. Int J Gynecol Pathol 2012-07-01 [PMID: 22653341]
Weigert O, Kopp N, Lane AA et al. Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation. Cancer Discov 2012-01-01 [PMID: 22585168] (IF/IHC, Human)	IF/IHC	Human
Yamamoto S, Tsuda H, Takano M et al. Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations. Mod Pathol 2012-04-01 [PMID: 22157930]
Yamamoto S et al. PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. Virchows Arch. 2011-11-26 [PMID: 22120431]
Wang K et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet. 2011-10-30 [PMID: 22037554]
Guan B, Mao TL, Panuganti PK et al. Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Am J Surg Pathol 2011-05-01 [PMID: 21412130]
Bolander A, Agnarsdottir M, Stromberg S et al. The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas. Cancer Genomics Proteomics 2008-11-01 [PMID: 19287070]
Show All 23 Publications. Collapse Publications.

Array NBP1-88932

• ARID1A Antibodies
• ARID1A Lysate
• ARID1A Proteins