WT1 Antibody

Wilm's Tumor (WT) is a 55 kDa protein thought to play a major role in various cancers and developmental disorders, commonly kidney tumors and glomerular diseases. WT is a zinc finger transcription factor that is mutated in Wilm's tumors and highly expressed in a wide variety of other malignancies (1). It is believed that WT in its two isoforms acts as both a transcription factor and a post-transcriptional regulator that binds RNA and can interact with splicing components (2). Mutations in the zinc finger regions of WT are detected in nearly all patients of Denys-Drash syndrome and in some patients with isolated diffuse mesangial sclerosis. Also, mutations leading to the loss of the transcription factor isoform have been observed in all patients with Frasier syndrome (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 2 of 2.

Publications using NBP1-31314	Applications	Species
Husain S, Ginawi I, Bashir AI et al. Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression. Ultrastruct Pathol. 2018-10-04 [PMID: 30285525] (IHC-P, Rat)	IHC-P	Rat
Lim Beom Jin, Yang Jae Won, Zou Jun et al. Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury. Kidney International 2017-01-01 [PMID: 28709637] (IF/IHC, Mouse)	IF/IHC	Mouse

Array NBP1-31314

• WT1 Antibodies
• WT1 ELISA Kits
• WT1 Lysate
• WT1 Proteins