Reactivity | HuSpecies Glossary |
Applications | Flow |
Clone | 1023426 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Alexa Fluor 594 |
Immunogen | Chinese Hamster Ovary cell line, CHO derived human TREM119 Arg26-Met96 Accession # Q4V9L6.1 |
Specificity | Detects human TREM119 in direct ELISAs. |
Source | N/A |
Isotype | IgG1 |
Clonality | Monoclonal |
Host | Mouse |
Purity Statement | Protein A or G purified from cell culture supernatant |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Protect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Buffer | Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide. |
TMEM119 (Transmembrane Protein 119, also known as Osteoblast Induction Factor or OBIF), is an approximately 38-kDa type 1 transmembrane protein that is predominantly expressed in osteoblasts and is upregulated during osteoblastic differentiation (1, 2). TMEM119 is also expressed in a cell line of microglia, and TMEM119 immunoreactivity is observed in a specific subset of microglia in brains of neurodegenerative diseases, such as Alzheimer's disease (3). Mature human TMEM119 consists of a 71 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 166 aa cytoplasmic domain. Within the ECD, human TMEM119 shares 78% and 75% aa sequence identity with mouse and rat TMEM119, respectively. TMEM-119 is involved in the osteoblast differentiation and bone development by acting as a ligand and has been reported to contribute to the proliferation, migration, and invasion of osteosarcoma cells, as well as functioning as an oncogene in osteosarcoma (3, 4).
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