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TGF-beta RII Antibody [Phycoerythrin]

 (17 Publications)
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Mouse splenocytes were stained with Goat Anti-Mouse TGF-beta RII PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB532P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Mouse splenocytes were stained with Goat Anti-Mouse TGF-beta RII PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB532P, filled histogram) or isotype control antibody (Catalog # IC108P, open ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clonality
Polyclonal
Host
Goat
Conjugate
Phycoerythrin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 700
FAB532N-100
Alexa Fluor 700
FAB532N-025
Allophycocyanin
FAB532A-100
Allophycocyanin
FAB532A-025
Biotin
BAF532
Fluorescein
FAB532F-100
Fluorescein
FAB532F-025
Phycoerythrin
FAB532P-025UG
Unconjugated
AF532
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF532
Carrier Free
AF532
Carrier Free
FAB532F-100
Carrier Free
FAB532A-100
Carrier Free
FAB532N-100
Carrier Free
FAB532A-025
Carrier Free
FAB532F-025
Carrier Free
FAB532N-025
Carrier Free
AF532-SP
Carrier Free
FAB532P-025UG
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TGF-beta RII Antibody [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TGF‑ beta  RII and S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TGF‑ beta  RII
Ile24-Asp184
Accession # Q62312
Specificity
Detects mouse TGF-beta  RII in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) TGF-beta  RII is observed and less than 1% cross-reactivity with recombinant mouse TGF-beta  RI and rhTGF-beta  RIII is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TGFBR2
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Publications
Read Publications using
FAB532P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RII Antibody [Phycoerythrin]

  • AAT3
  • EC 2.7.11
  • EC 2.7.11.30
  • FAA3
  • HNPCC6
  • LDS1B
  • LDS2B
  • MFS2
  • RIIC
  • TAAD2
  • tbetaR-II
  • TGF-beta receptor type II
  • TGF-beta receptor type IIB
  • TGF-beta receptor type-2
  • TGF-beta RII
  • TGF-beta type II receptor
  • TGFbetaRII
  • TGFbeta-RII
  • TGFBR2
  • TGF-bRII
  • TGFR-2
  • transforming growth factor beta receptor type IIC
  • transforming growth factor, beta receptor II (70/80kDa) isoform 1
  • transforming growth factor, beta receptor II (70/80kDa) isoform 2
  • transforming growth factor, beta receptor II (70/80kDa)
  • transforming growth factor, beta receptor II (70-80kD)
  • Transforming growth factor-beta receptor type II

Background

Most cell types express three sizes of receptors for TGF-beta . These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta . Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.

The recombinant soluble TGF-beta Type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta Type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta .

  1. Miyazono, K. et al. (1994) Adv. in Immunol. 55:181.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TGF-beta RII
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FAB532P
TGF-beta RII Antibody [Phycoerythrin]
Species: Mu
Applications: Flow

Publications for TGF-beta RII Antibody (FAB532P)(17)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.


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Flow Cytometry
(13)
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Mouse
(13)
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Showing Publications 1 - 10 of 17. Show All 17 Publications.
Publications using FAB532P Applications Species
Zhang, C;Liu, X;Gu, C;Su, Y;Lv, J;Liu, Y;Gao, Y;Chen, H;Xu, N;Xiao, J;Xu, Z;Su, W; Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis Journal of advanced research 2024-08-05 [PMID: 39107200] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Barnkob, MB;Michaels, YS;André, V;Macklin, PS;Gileadi, U;Valvo, S;Rei, M;Kulicke, C;Chen, JL;Jain, V;Woodcock, VK;Colin-York, H;Hadjinicolaou, AV;Kong, Y;Mayya, V;Mazet, JM;Mead, GJ;Bull, JA;Rijal, P;Pugh, CW;Townsend, AR;Gérard, A;Olsen, LR;Fritzsche, M;Fulga, TA;Dustin, ML;Jones, EY;Cerundolo, V; Semmaphorin 3?A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells Nature communications 2024-04-12 [PMID: 38609390] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Gu, C;Liu, Y;Lv, J;Zhang, C;Huang, Z;Jiang, Q;Gao, Y;Tao, T;Su, Y;Chen, B;Jia, R;Liu, X;Su, W; Kurarinone regulates Th17/Treg balance and ameliorates autoimmune uveitis via Rac1 inhibition Journal of advanced research 2024-03-22 [PMID: 38522752] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Liu, X;Gu, C;Lv, J;Jiang, Q;Ding, W;Huang, Z;Liu, Y;Su, Y;Zhang, C;Xu, Z;Wang, X;Su, W; Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis Journal of neuroinflammation 2023-06-21 [PMID: 37344856] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Lynda Zeboudj, George Sideris-Lampretsas, Rita Silva, Sabeha Al-Mudaris, Francesca Picco, Sarah Fox et al. Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-beta –related pathway in macrophages Journal of Clinical Investigation 6/1/2023 [PMID: 37071481]
TL Kieu, L Pierre, V Derangère, S Perrey, C Truntzer, A Jalil, S Causse, E Groetz, A Dumont, L Guyard, L Arnould, JP de Barros, L Apetoh, C Rébé, E Limagne, T Jourdan, L Demizieux, D Masson, C Thomas, F Ghiringhel, M Rialland Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-beta receptors Cell Death & Disease, 2022-09-02;13(9):758. 2022-09-02 [PMID: 36056008] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Ying Fu, Zhiming Wang, Baichao Yu, Yuli Lin, Enyu Huang, Ronghua Liu et al. Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A Frontiers in Immunology 11/3/2021 [PMID: 34804004]
A Osman, B Yan, Y Li, KD Pavelko, J Quandt, A Saadalla, MP Singh, M Kazemian, F Gounari, K Khazaie TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer Nature Immunology, 2021-08-12;0(0):. 8/12/2021 [PMID: 34385712]
H Xu, T Agalioti, J Zhao, B Steglich, R Wahib, MCA Vesely, P Bielecki, W Bailis, R Jackson, D Perez, J Izbicki, P Licona-Lim, V Kaartinen, J Geginat, E Esplugues, E Tolosa, S Huber, RA Flavell, N Gagliani The induction and function of the anti-inflammatory fate of TH17 cells Nat Commun, 2020-07-03;11(1):3334. 2020-07-03 [PMID: 32620760] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Sun X, Cui Y, Feng H et al. TGF-beta signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity J. Exp. Med. 9/12/2019 [PMID: 31515281]
Show All 17 Publications.

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Bioinformatics

Gene Symbol TGFBR2
Uniprot