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Recombinant Human TGF-beta 2 Protein

Name: Recombinant Human TGF-beta 2 Protein
Brand: Novus Biologicals
SKU: 302-B2
Price: 420 USD

(86 Publications)

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Recombinant Human TGF-beta 2 (Catalog # 302-B2) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced cell proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.025-0.25 ng/mL.

1 μg/lane of Recombinant Human TGF-beta 2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 12 kDa and 24 kDa, respectively.

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	Bioactivity

Order Details

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Catalog# & Formulation	Size	Price
Carrier Free 302-B2-002/CF

Carrier Free 302-B2-010/CF

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Recombinant Human TGF-beta 2 Protein Summary

Details of Functionality	Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED₅₀ for this effect is 0.025-0.25 ng/mL.
Source	Mouse myeloma cell line, NS0-derived human TGF-beta 2 protein Ala303-Ser414
Accession #	P61812
N-terminal Sequence	Ala303
Structure / Form	Disulfide-linked homodimer
Protein/Peptide Type	Recombinant Proteins
Gene	TGFB2
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

12.7 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

12 kDa, reducing conditions
24 kDa, non-reducing conditions

Publications

Read Publications using
302-B2 in the following applications:

Bioassay
76 publications
Cell Culture
5 publications
ELISA (Standard)
2 publications
In Vivo
2 publications
Surface Plasmon Resonance
1 publication
Western Blot
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions	Reconstitute at 20 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TGF-beta 2 Protein

BSC-1 cell growth inhibitor
cetermin
Glioblastoma-derived T-cell suppressor factor
G-TSF
MGC116892
polyergin
TGFB2
TGFbeta 2
TGF-beta 2
TGF-beta2
TGF-beta-2
transforming growth factor beta-2
transforming growth factor, beta 2

Background

TGF-beta 2 (transforming growth factor beta 2) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cysteine knot structure (1-7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1-4). Each TGF-beta isoform has some non-redundant functions; for TGF-beta 2, mice with targeted deletion show defects in development of cardiac, lung, craniofacial, limb, eye, ear and urogenital systems (2). Human TGF-beta 2 cDNA encodes a 414 amino acid (aa) precursor that contains a 19 aa signal peptide and a 395 aa proprotein (8). A furin-like convertase processes the proprotein to generate an N-terminal 232 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF- beta 2 (8, 9). Disulfide-linked homodimers of LAP and TGF-beta 2 remain non-covalently associated after secretion, forming the small latent TGF-beta 1 complex (8-10). Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature human TGF-beta 2 shows 100% aa identity with porcine, canine, equine and bovine TGF-beta 2, and 97% aa identity with mouse and rat TGF-beta 2. It demonstrates cross-species activity (1). TGF-beta 2 signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II ser/thr kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates another ser/thr kinase receptor, TGF-beta RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK-1. The whole complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Use of other signaling pathways that are Smad-independent allows for disparate actions observed in response to TGF-beta in different contexts (11).

Sporn, M.B. (2006) Cytokine Growth Factor Rev. 17:3.
Dunker, N. and K. Krieglstein, 2000, Eur. J. Biochem. 267:6982.
Wahl, S.M. (2006) Immunol. Rev. 213:213.
Chang, H. et al. (2002) Endocr. Rev. 23:787.
Lin, J.S. et al. (2006) Reproduction 132:179.
Hinck, A.P. et al. (1996) Biochemistry 35:8517.
Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
deMartin, R. et al. (1987) EMBO J. 6:3673.
Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.

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Recombinant Human
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Publications for TGF-beta 2 (302-B2)(86)

We have publications tested in 7 confirmed species: Human, Mouse, Rat, Canine, Chicken, Cynomolgus Monkey, Primate - Macaca fascicularis (Cynomolgus Macaque).

We have publications tested in 6 applications: Bioassay, Cell Culture, ELISA (Standard), In Vivo, Surface Plasmon Resonance, Western Blot.

Showing Publications 1 - 10 of 86. Show All 86 Publications.

Publications using 302-B2	Applications	Species
Choi, AS;Jenkins-Lane, LM;Barton, W;Kumari, A;Lancaster, C;Raulerson, C;Ji, H;Altomare, D;Starr, MD;Whitaker, R;Phaeton, R;Arend, R;Shtutman, M;Nixon, AB;Hempel, N;Lee, NY;Mythreye, K; Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-? signaling bioRxiv : the preprint server for biology 2023-08-29 [PMID: 37693479] (Bioassay, Human)	Bioassay	Human
Voss, AJ;Lanjewar, SN;Sampson, MM;King, A;Hill, EJ;Sing, A;Sojka, C;Bhatia, TN;Spangle, JM;Sloan, SA; Identification of ligand-receptor pairs that drive human astrocyte development Nature neuroscience 2023-07-17 [PMID: 37460808] (Bioassay, Human)	Bioassay	Human
Fujimoto, T;Inoue-Mochita, M;Inoue, T; A ROCK inhibitor suppresses the transforming growth factor-beta-2-induced endothelial-mesenchymal transition in Schlemm's canal endothelial cells Scientific reports 2023-06-14 [PMID: 37316554] (Bioassay, Primate - Macaca fascicularis (Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Cynomolgus Macaque)
Jang, HY;Kim, SJ;Park, KS;Kim, JH; Klotho prevents transforming growth factor-?2-induced senescent-like morphological changes in the retinal pigment epithelium Cell death & disease 2023-05-20 [PMID: 37210384] (Bioassay, Human)	Bioassay	Human
BR Jin, HJ Kim, JH Na, WK Lee, HJ An Targeting benign prostate hyperplasia treatments: AR/TGF-beta/NOX4 inhibition by apocynin suppresses inflammation and proliferation Journal of advanced research, 2023-04-14;0(0):. 2023-04-14 [PMID: 37061215] (Bioassay, Human)	Bioassay	Human
H Han, Y Yang, Z Han, L Wang, L Dong, H Qi, B Liu, J Tian, B Vanhaesebr, A Kazlauskas, G Zhang, S Zhang, H Lei NFkappaB-Mediated Expression of Phosphoinositide 3-Kinase delta Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells Cells, 2023-01-04;12(2):. 2023-01-04 [PMID: 36672142] (Bioassay, Human)	Bioassay	Human
M Morita, A Yoneda, N Tokunoh, T Masaki, K Shirakura, M Kinoshita, R Hashimoto, N Shigesada, J Takahashi, M Tachibana, S Tanaka, M Obana, N Hino, M Ikawa, K Tsujikawa, C Ono, Y Matsuura, H Kidoya, N Takakura, Y Kubota, T Doi, K Takayama, Y Yoshioka, Y Fujio, Y Okada Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models Proceedings of the National Academy of Sciences of the United States of America, 2023-01-12;120(3):e2213317120. 2023-01-12 [PMID: 36634143] (Bioassay, Human)	Bioassay	Human
B Kramer, C Corallo, A van den He, J Crawford, T Olivier, E Elstak, N Giordano, P Vulto, HL Lanz, RAJ Janssen, MA Tessari High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis Scientific Reports, 2022-10-08;12(1):16930. 2022-10-08 [PMID: 36209279] (Bioassay, Human)	Bioassay	Human
K Santerre, S Cortez Ghi, S Proulx TGF-beta-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells Investigative Ophthalmology & Visual Science, 2022-10-03;63(11):3. 2022-10-03 [PMID: 36194422] (Bioassay, Human)	Bioassay	Human
J Knox, G Bou-Ghario, KJ Hamill, CE Willoughby MiR-18a-5p Targets Connective Tissue Growth Factor Expression and Inhibits Transforming Growth Factor beta2-Induced Trabecular Meshwork Cell Contractility Genes, 2022-08-22;13(8):. 2022-08-22 [PMID: 36011411] (Bioassay, Human)	Bioassay	Human
B Callaghan, K Lester, B Lane, X Fan, K Goljanek-W, DA Simpson, C Sheridan, CE Willoughby Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-beta2 Oncogene, 2022-06-10;12(1):9564. 2022-06-10 [PMID: 35689009] (Bioassay, Human)	Bioassay	Human
A Utsunomiya, T Chino, H Kasamatsu, T Hasegawa, N Utsunomiya, VH Luong, T Matsushita, Y Sasaki, D Ogura, SI Niwa, N Oyama, M Hasegawa The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-beta signaling Arthritis Research & Therapy, 2022-04-29;24(1):94. 2022-04-29 [PMID: 35488265] (Bioassay, Human)	Bioassay	Human
K Sobierajsk, ME Wawro, J Niewiarows Oxidative Stress Enhances the TGF-beta2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition International Journal of Molecular Sciences, 2022-02-13;23(4):. 2022-02-13 [PMID: 35216178] (Bioassay, Human)	Bioassay	Human
RB Kasetti, P Maddineni, B Kodati, B Nagarajan, S Yacoub Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFbeta2 Induced Primary Open Angle Glaucoma International Journal of Molecular Sciences, 2021-11-19;22(22):. 2021-11-19 [PMID: 34830390] (Bioassay, Human)	Bioassay	Human
ZZG Liu, A Taiyab, JA West-Mays MMP9 Differentially Regulates Proteins Involved in Actin Polymerization and Cell Migration during TGF-beta-Induced EMT in the Lens International Journal of Molecular Sciences, 2021-11-05;22(21):. 2021-11-05 [PMID: 34769418] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
E Takahashi, J Saruwatari, T Fujimoto, Y Tanoue, T Fukuda, T Inoue The effects of exosomes derived from trabecular meshwork cells on Schlemm's canal endothelial cells Scientific Reports, 2021-11-09;11(1):21942. 2021-11-09 [PMID: 34754027] (Bioassay, Cynomolgus Monkey)	Bioassay	Cynomolgus Monkey
CC Hsiao, YC Chang, YT Hsiao, PH Chen, MC Hsieh, WC Wu, YH Kao Triamcinolone acetonide modulates TGF?beta2?induced angiogenic and tissue?remodeling effects in cultured human retinal pigment epithelial cells Molecular Medicine Reports, 2021-09-15;24(5):. 2021-09-15 [PMID: 34523693] (Bioassay, Human)	Bioassay	Human
T Tabib, M Huang, N Morse, A Papazoglou, R Behera, M Jia, M Bulik, DE Monier, PV Benos, W Chen, R Domsic, R Lafyatis Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin Nature Communications, 2021-07-19;12(1):4384. 2021-07-19 [PMID: 34282151] (Bioassay, Human)	Bioassay	Human
NN Lopez, R Rangan, AF Clark, T Tovar-Vida Mirna Expression in Glaucomatous and TGFbeta2 Treated Lamina Cribrosa Cells International Journal of Molecular Sciences, 2021-06-08;22(12):. 2021-06-08 [PMID: 34201109] (Bioassay, Human)	Bioassay	Human
WT Shelton, SM Thomas, HR Alexander, CE Thomes, DE Conway, AD Dubash Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion Scientific Reports, 2021-06-24;11(1):13295. 2021-06-24 [PMID: 34168237] (Cell Culture, Human)	Cell Culture	Human
C Ota, Y Ida, H Ohguro, F Hikage ROCK inhibitors beneficially alter the spatial configuration of TGF&beta2-treated 3D organoids from a human trabecular meshwork (HTM) Sci Rep, 2020-11-20;10(1):20292. 2020-11-20 [PMID: 33219246] (Cell Culture, Human)	Cell Culture	Human
T Matsumura, T Fujimoto, A Futakuchi, Y Takihara, F Watanabe-K, E Takahashi, M Inoue-Moch, H Tanihara, T Inoue TGF-&beta-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness PLoS ONE, 2020-11-18;15(11):e0242626. 2020-11-18 [PMID: 33206726] (Cell Culture, Human)	Cell Culture	Human
F Yemanyi, J Vranka, VK Raghunatha Glucocorticoid-induced cell-derived matrix modulates transforming growth factor &beta2 signaling in human trabecular meshwork cells Scientific Reports, 2020-09-24;10(1):15641. 2020-09-24 [PMID: 32973273] (Bioassay, Human)	Bioassay	Human
S Rathi, I Danford, HV Gudiseva, L Verkuil, M Pistilli, S Vishwakarm, I Kaur, T Dave, JM O'Brien, VRM Chavali Molecular Genetics and Functional Analysis Implicate CDKN2BAS1-CDKN2B Involvement in POAG Pathogenesis Cells, 2020-08-21;9(9):. 2020-08-21 [PMID: 32825664] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
JA Faralli, MS Filla, CM McDowell, DM Peters Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB/cJ mice PLoS ONE, 2020-08-21;15(8):e0237932. 2020-08-21 [PMID: 32822410] (Bioassay, Mouse)	Bioassay	Mouse
Y Fan, J Wei, L Guo, S Zhao, C Xu, H Sun, T Guo Osthole Reduces Mouse IOP Associated With Ameliorating Extracellular Matrix Expression of Trabecular Meshwork Cell Invest. Ophthalmol. Vis. Sci., 2020-08-03;61(10):38. 2020-08-03 [PMID: 32821914] (Bioassay, Human)	Bioassay	Human
SK Meurer, O Tezcan, T Lammers, R Weiskirche Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells Cell. Signal., 2020-08-03;74(0):109731. 2020-08-03 [PMID: 32758668] (Bioassay, Human)	Bioassay	Human
DC Briggs, AWW Langford-S, HL Birchenoug, TA Jowitt, CM Kielty, JJ Enghild, C Baldock, CM Milner, AJ Day Inter-&alpha-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation J. Biol. Chem., 2020-03-06;0(0):. 2020-03-06 [PMID: 32144206] (Surface Plasmon Resonance)	Surface Plasmon Resonance
H Yonemura, A Futakuchi, M Inoue-Moch, T Fujimoto, E Takahashi, H Tanihara, T Inoue DNA methyltransferase inhibitor suppresses fibrogenetic changes in human conjunctival fibroblasts Mol. Vis., 2019-07-21;25(0):382-390. 2019-07-21 [PMID: 31523116] (Bioassay, Human)	Bioassay	Human
Wei X, Zhang L, Zhou Z, Kwon O, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo M, Xu F, Creighton C, Ittmann M, Xin L Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell, 2019-04-11;24(5):753-768.e6. 2019-04-11 [PMID: 30982770] (Bioassay, Mouse)	Bioassay	Mouse
M Rutgers, F Bach, L Vonk, M van Rijen, V Akrum, A van Boxtel, W Dhert, L Creemers PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation PLoS ONE, 2019-04-04;14(4):e0213483. 2019-04-04 [PMID: 30947269] (Bioassay, Human)	Bioassay	Human
H Feng, X Zhao, Q Guo, Y Feng, M Ma, W Guo, X Dong, C Deng, C Li, X Song, S Han, L Cao Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis Int. J. Biol. Sci., 2019-01-01;15(3):507-521. 2019-01-01 [PMID: 30745838] (Bioassay, Human)	Bioassay	Human
M Kobayashi, K Tokuda, Y Kobayashi, C Yamashiro, SH Uchi, M Hatano, K Kimura Suppression of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells by an MRTF-A Inhibitor Invest. Ophthalmol. Vis. Sci., 2019-02-01;60(2):528-537. 2019-02-01 [PMID: 30707754] (Bioassay, Human)	Bioassay	Human
C Ozek, RC Krolewski, SM Buchanan, LL Rubin Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice Sci Rep, 2018-11-23;8(1):17293. 2018-11-23 [PMID: 30470794] (Bioassay, Mouse)	Bioassay	Mouse
CG Abraham, MP Ludwig, Z Andrysik, A Pandey, M Joshi, MD Galbraith, KD Sullivan, JM Espinosa ?Np63? Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas Cell Rep, 2018-09-18;24(12):3224-3236. 2018-09-18 [PMID: 30232004] (Bioassay, Human)	Bioassay	Human
M Inoue-Moch, T Inoue, S Kojima, A Futakuchi, T Fujimoto, S Sato-Ohira, U Tsutsumi, H Tanihara Interleukin-6-mediated trans-signaling inhibits transforming growth factor-? signaling in trabecular meshwork cells J. Biol. Chem., 2018-05-11;0(0):. 2018-05-11 [PMID: 29752408] (Bioassay, Human)	Bioassay	Human
CC Tsai, SB Wu, HC Kau, YH Wei Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts Sci Rep, 2018-05-08;8(1):7276. 2018-05-08 [PMID: 29739987] (Bioassay, Human)	Bioassay	Human
JUG Wagner, E Chavakis, EM Rogg, M Muhly-Rein, SF Glaser, S Günther, D John, F Bonini, AM Zeiher, L Schaefer, MJ Hannocks, RA Boon, S Dimmeler Switch in Laminin Î²2 to Laminin Î²1 Isoforms During Aging Controls Endothelial Cell Functions Arterioscler. Thromb. Vasc. Biol., 2018-03-29;0(0):. 2018-03-29 [PMID: 29599141] (Cell Culture, Human)	Cell Culture	Human
U Tsutsumi-K, T Inoue, A Futakuchi, K Shobayashi, E Takahashi, S Kojima, M Inoue-Moch, T Fujimoto, H Tanihara Decreased MCP-1/CCR2 axis-mediated chemotactic effect of conjunctival fibroblasts after transdifferentiation into myofibroblasts Exp. Eye Res., 2018-02-17;170(0):76-80. 2018-02-17 [PMID: 29458061] (Bioassay, Human)	Bioassay	Human
J Nishida, K Miyazono, S Ehata Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms Oncogene, 2018-02-02;0(0):. 2018-02-02 [PMID: 29391598] (Bioassay, Human)	Bioassay	Human
J Wu, X Chen, X Liu, S Huang, C He, B Chen, Y Liu Autophagy regulates TGF-?2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells Mol Med Rep, 2017-12-27;0(0):. 2017-12-27 [PMID: 29286127] (Bioassay, Human)	Bioassay	Human
JD Glover, KL Wells, F Matthäus, KJ Painter, W Ho, J Riddell, JA Johansson, MJ Ford, CAB Jahoda, V Klika, RL Mort, DJ Headon Hierarchical patterning modes orchestrate hair follicle morphogenesis PLoS Biol., 2017-07-11;15(7):e2002117. 2017-07-11 [PMID: 28700594] (Bioassay, Mouse)	Bioassay	Mouse
N Selvamurug, Z He, D Rifkin, B Dabovic, NC Partridge Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-? Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation Stem Cells Int, 2017-04-23;2017(0):2450327. 2017-04-23 [PMID: 28512472] (Bioassay, Human)	Bioassay	Human
E Ventura, M Weller, I Burghardt Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells J. Immunol., 2017-05-08;0(0):. 2017-05-08 [PMID: 28484053] (Bioassay, Human)	Bioassay	Human
A Futakuchi, T Inoue, T Fujimoto, U Kuroda, M Inoue-Moch, E Takahashi, S Ohira, H Tanihara Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA) Invest. Ophthalmol. Vis. Sci., 2017-04-01;58(4):2421-2429. 2017-04-01 [PMID: 28448670] (Bioassay, Human)	Bioassay	Human
N Tellios, JC Belrose, AC Tokarewicz, C Hutnik, H Liu, A Leask, M Motolko, M Iijima, SK Parapuram TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma Sci Rep, 2017-04-11;7(1):812. 2017-04-11 [PMID: 28400560] (Bioassay, Human)	Bioassay	Human
MC Wojciechow, L Mahmutovic, DY Shu, FJ Lovicu ERK1/2 signaling is required for the initiation but not progression of TGF?-induced lens epithelial to mesenchymal transition (EMT) Exp. Eye Res., 2017-03-30;159(0):98-113. 2017-03-30 [PMID: 28365272] (Bioassay, Human)	Bioassay	Human
BA Boswell, A Korol, JA West-Mays, LS Musil Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract Mol. Biol. Cell, 2017-02-16;0(0):. 2017-02-16 [PMID: 28209733] (Bioassay, Chicken)	Bioassay	Chicken
MM Roe, S Swain, TA Sebrell, MA Sewell, MM Collins, BA Perrino, PD Smith, LE Smythies, D Bimczok Differential regulation of CD103 (ï¿½E integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands J. Leukoc. Biol, 2017-01-13;0(0):. 2017-01-13 [PMID: 28087652] (Bioassay, Human)	Bioassay	Human
TGF?2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor Sci Rep, 2016-12-07;6(0):38319. 2016-12-07 [PMID: 27924833] (Bioassay, Human)	Bioassay	Human
Sang Il Gum Cyclosporine A inhibits TGF-?2-induced myofibroblasts of primary cultured human pterygium fibroblasts Biochem. Biophys. Res. Commun, 2016-12-02;0(0):. 2016-12-02 [PMID: 27919682] (Bioassay, Human)	Bioassay	Human
Michio Nakaya Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction J. Clin. Invest, 2016-12-05;0(0):. 2016-12-05 [PMID: 27918308] (Bioassay, Human)	Bioassay	Human
Karthikeyan Mythreye Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling J. Biol. Chem., 2016-10-26;291(49):25716-25728. 2016-10-26 [PMID: 27784788] (Bioassay, Human)	Bioassay	Human
Transient RUNX1 Expression during Early Mesendodermal Differentiation ofï¿½hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling Stem Cell Reports, 2016-10-06;7(5):884-896. 2016-10-06 [PMID: 27720906] (Bioassay, Human)	Bioassay	Human
A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516 PLoS ONE, 2016-09-13;11(9):e0162394. 2016-09-13 [PMID: 27622654] (Bioassay, Human)	Bioassay	Human
K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2 J Cell Sci, 2016-08-05;0(0):. 2016-08-05 [PMID: 27505893] (Bioassay, Mouse)	Bioassay	Mouse
Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat Med, 2015-04-20;21(5):530-6. 2015-04-20 [PMID: 25894825] (Bioassay, Human)	Bioassay	Human
Reeves S, Kolstad T, Lien T, Herrington-Shaner S, Debley J Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children. Respir Res, 2015-02-13;16(1):21. 2015-02-13 [PMID: 25849331] (Bioassay, Human)	Bioassay	Human
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62. 2015-01-20 [PMID: 25604685] (Bioassay, Human)	Bioassay	Human
Villarreal G, Chatterjee A, Oh S, Oh D, Kang M, Rhee D Canonical wnt signaling regulates extracellular matrix expression in the trabecular meshwork. Invest Ophthalmol Vis Sci, 2014-10-28;55(11):7433-40. 2014-10-28 [PMID: 25352117] (Bioassay, Human)	Bioassay	Human
Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE, 2014-05-09;9(5):e96615. 2014-05-09 [PMID: 24816923] (Bioassay, Human)	Bioassay	Human
Gerhart J, Greenbaum M, Scheinfeld V, Fitzgerald P, Crawford M, Bravo-Nuevo A, Pitts M, George-Weinstein M Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens. PLoS ONE, 2014-04-15;9(4):e95262. 2014-04-15 [PMID: 24736495] (Bioassay, Human)	Bioassay	Human
Neumann C, Garreis F, Paulsen F, Hammer C, Birke M, Scholz M Osteopontin is induced by TGF-beta2 and regulates metabolic cell activity in cultured human optic nerve head astrocytes. PLoS ONE, 2014-04-09;9(4):e92762. 2014-04-09 [PMID: 24718314] (Bioassay, Human)	Bioassay	Human
Echeverria C, Montorfano I, Hermosilla T, Armisen R, Velasquez L, Cabello-Verrugio C, Varela D, Simon F Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS ONE, 2014-04-07;9(4):e94146. 2014-04-07 [PMID: 24710004] (Bioassay, Human)	Bioassay	Human
Kimura K, Orita T, Fujitsu Y, Liu Y, Wakuta M, Morishige N, Suzuki K, Sonoda K Inhibition by female sex hormones of collagen gel contraction mediated by retinal pigment epithelial cells. Invest Ophthalmol Vis Sci, 2014-04-21;55(4):2621-30. 2014-04-21 [PMID: 24609629] (Bioassay, Mouse)	Bioassay	Mouse
Villarreal G, Chatterjee A, Oh S, Oh D, Rhee D Pharmacological regulation of SPARC by lovastatin in human trabecular meshwork cells. Invest Ophthalmol Vis Sci, 2014-03-19;55(3):1657-65. 2014-03-19 [PMID: 24474275] (Bioassay, Human)	Bioassay	Human
Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, Sieber-Blum M Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury. Stem Cells Transl Med, 2014-01-17;3(3):334-45. 2014-01-17 [PMID: 24443004] (Bioassay, Canine)	Bioassay	Canine
Volkmann I, Kumarswamy R, Pfaff N, Fiedler J, Dangwal S, Holzmann A, Batkai S, Geffers R, Lother A, Hein L, Thum T MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circ Res, 2013-08-19;113(8):997-1003. 2013-08-19 [PMID: 23960241] (Bioassay, Human)	Bioassay	Human
Kolpa , Heather, Peal , David S, Lynch , Stacey N, Giokas , Andrea C, Ghatak , Shibnath, Misra , Suniti, Norris , Russell, Macrae , Calum A, Markwald , Roger R, Ellinor , Patrick, Bischoff , Joyce, Milan , David J miR-21 represses Pdcd4 during cardiac valvulogenesis. Development, 2013-04-11;140(10):2172-80. 2013-04-11 [PMID: 23578931] (Bioassay, Human)	Bioassay	Human
TGFbeta signalling plays an important role in IL4-induced alternative activation of microglia. J Neuroinflammation, 2012-09-04;9(0):210. 2012-09-04 [PMID: 22947253] (Bioassay, Mouse)	Bioassay	Mouse
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Cursiefen C, Maruyama K, Bock F, Saban D, Sadrai Z, Lawler J, Dana R, Masli S Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J. Exp. Med., 2011-05-02;208(5):1083-92. 2011-05-02 [PMID: 21536744] (Bioassay, Mouse)	Bioassay	Mouse
Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol. Biol. Cell, 2011-03-16;22(10):1686-98. 2011-03-16 [PMID: 21411626] (Bioassay, Canine)	Bioassay	Canine
Craig EA, Craig E, Austin AF, Austin A, Vaillancourt RR, Vaillancourt R, Barnett JV, Camenisch TD, Camenisch T TGFbeta2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion. Exp Cell Res, 2010-07-13;316(20):3397-405. 2010-07-13 [PMID: 20633555] (Bioassay, Mouse)	Bioassay	Mouse
Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J. Biol. Chem., 2009-12-03;285(0):4975-82. 2009-12-03 [PMID: 19959467] (In Vivo, Mouse)	In Vivo	Mouse
Kuchtey J, Kallberg ME, Gelatt KN, Rinkoski T, Komaromy AM, Kuchtey RW Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. Invest. Ophthalmol. Vis. Sci., 2008-04-17;49(8):3438-48. 2008-04-17 [PMID: 18421092] (Bioassay, Human)	Bioassay	Human
Barkho BZ, Song H, Aimone JB Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev., 2006-06-01;15(3):407-21. 2006-06-01 [PMID: 16846377] (Bioassay, Rat)	Bioassay	Rat
Neurohr C, Nishimura SL, Sheppard D Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9. 2006-03-30 [PMID: 16574941] (Bioassay, Human)	Bioassay	Human
Close JL, Gumuscu B, Reh TA Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling. Development, 2005-07-01;132(13):3015-26. 2005-07-01 [PMID: 15944186] (Bioassay, Rat)	Bioassay	Rat
Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)	Bioassay	Human
Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Yoo J, Flanders KC, Roberts AB Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice. Lab. Invest., 2004-10-01;84(10):1245-58. 2004-10-01 [PMID: 15273699] (Bioassay, Human)	Bioassay	Human
Murphy SJ, Dore JJ, Edens M, Coffey RJ, Barnard JA, Mitchell H, Wilkes M, Leof EB Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells. Mol. Biol. Cell, 2004-04-09;15(6):2853-62. 2004-04-09 [PMID: 15075369] (Bioassay, Canine)	Bioassay	Canine
Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22. 2004-01-12 [PMID: 14722222] (ELISA (Standard))	ELISA (Standard)
Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56. 2002-05-01 [PMID: 11943670] (ELISA (Standard))	ELISA (Standard)
Jiang Y, Zhang M, Koishi K, McLennan IS TGF-beta 2 attenuates the injury-induced death of mature motoneurons. J. Neurosci. Res., 2000-12-15;62(6):809-13. 2000-12-15 [PMID: 11107165] (In Vivo, Rat)	In Vivo	Rat
Mozes MM, Hodics T, Kopp JB Isoform specificity of commercially-available anti-TGF-beta antibodies. J. Immunol. Methods, 1999-05-27;225(1):87-93. 1999-05-27 [PMID: 10365785] (Western Blot)	Western Blot
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Gene Symbol	TGFB2
Uniprot	P61812()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

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