Serpin E1/PAI-1 Antibody - BSA Free

PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 9 applications: ELISA, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, Immunocytochemistry/ Immunofluorescence, WB, Western Blot.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using NBP1-19773	Applications	Species
Samarkina A, Youssef MK, Ostano P et al. Androgen receptor is a determinant of melanoma targeted drug resistance Nature communications 2023-10-14 [PMID: 37838724] (Western Blot, Immunocytochemistry/ Immunofluorescence, Human)	Western Blot, Immunocytochemistry/ Immunofluorescence	Human
Qu F, Brough SC, Michno W et al. Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis Nature cell biology 2023-10-01 [PMID: 37783795]
Wang X, Guo L, Huang J et al. Plasminogen Activator Inhibitor-1 Potentiates Neutrophil Infiltration and Tissue Injury in Colitis International Journal of Biological Sciences 2023-04-18 [PMID: 37151884]
Liu B, Kong Y, Alimi OA et al. Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention ACS nano 2023-02-28 [PMID: 36779870]
Ghosh AK, Kalousdian AA, Shang M et al. Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload Cellular signalling 2022-12-27 [PMID: 36584735] (IHC, Mouse)	IHC	Mouse
Zhu X, Schrader JM, Irizarry BA et al. Impact of A beta 40 and A beta 42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia Biomedicines 2022-11-19 [PMID: 36428550] (IHC-Fr, Rat) Details: Fifteen-month-old rTgF344-AD rat brain sections, dilution used 1:200	IHC-Fr	Rat
Bertelli PM, Pedrini E, Hughes D et al. Long term high glucose exposure induces premature senescence in retinal endothelial cells Frontiers in Physiology 2022-08-26 [PMID: 36091370]
Hasuike Y, Mochizuki H, Nakamori M. Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells Frontiers in Genetics 2022-03-25 [PMID: 35401669] (Western Blot)	Western Blot
Gao J, Wen J, Hu D et al. Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion Bioactive Materials 2022-02-01 [PMID: 35386330] (IF/IHC, Rat)	IF/IHC	Rat
Hu BA, Sai WW, Yuan J et al. PGF2 alpha-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway Oxidative medicine and cellular longevity 2022-01-27 [PMID: 35126810] (WB, Rat, Mouse)	WB	Rat, Mouse
Zhang S, Cao Y, Du J Et al. Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021-09-01 [PMID: 34449927] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Chen Dy, Khan N, Close Bj Et Al. SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway Journal of virology 2021-07-14 [PMID: 34260266]
Sun H, Pratt RE, Hodgkinson CP, Dzau VJ Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy Am J Physiol Cell Physiol 2020-10-07 [PMID: 33026832]
Lee YK, Kwon SM, Lee EB et al. Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis Cancers 2020-09-15 [PMID: 32942643] (WB, Human)	WB	Human
Ishiwata S, Iizuka H, Sonoda H et al. Upregulated miR-224-5p suppresses osteoblast differentiation by increasing the expression of Pai-1 in the lumbar spine of a rat model of congenital kyphoscoliosis Mol. Cell. Biochem. 2020-08-03 [PMID: 32748313] (WB)	WB
Kimura N, Nakagami G, Minematsu T, Sanada H Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models J Tissue Viability 2019-11-04 [PMID: 31757582] (IF/IHC, IHC-P, Mouse)	IF/IHC, IHC-P	Mouse
Mallikarjuna P, Raviprakash TS, Aripaka K et al. Interactions between TGF-beta type I receptor and hypoxia-inducible factor-alpha mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma Cell Cycle 2019-09-01 [PMID: 31339433]
LaRocca TJ, Mariani A, Watkins LR et al. TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes Neurobiol. Dis. 2019-06-20 [PMID: 31229690] (ICC/IF, Rat)	ICC/IF	Rat
Delfarah A, Parrish S et al. Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells. J Biol Chem 2019-05-07 [PMID: 31138644] (WB, Human)	WB	Human
Zhong Y, Zhang Y, Xu J et al. Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Nanoparticles for Thrombolysis without Vascular Damage: A Synergistic Nonpharmaceutical Strategy ACS Nano 2019-03-26 [PMID: 30855938] (IF/IHC, Rat)	IF/IHC	Rat
Cheng Q, Tong F, Shen Y et al. Achyranthes bidentata polypeptide k improves long-term neurological outcomes through reducing downstream microvascular thrombosis in experimental ischemic stroke. Lepr Rev. 2018-03-01 [PMID: 30414726] (WB, IF/IHC, Rat)	WB, IF/IHC	Rat
PriYadarshini R, Hussain M, Attri P et al. BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor. Cell Rep. 2018-07-24 [PMID: 30044990] (WB)	WB
Hiebert P, Wietecha MS, Cangkrama M et al. Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome. Dev. Cell. 2018-07-16 [PMID: 30016619] (Mouse)		Mouse
Mallikarjuna P, Sitaram RT, Landstrom M, Ljungberg B. VHL status regulates transforming growth factor-b signaling pathways in renal cell carcinoma. Oncotarget 2018-03-27 [PMID: 29662646] (WB, Human)	WB	Human
Gerenu G, Martisova E, Ferrero H et al. Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits Biochim. Biophys. Acta 2017-01-26 [PMID: 28132883] (ELISA, Mouse)	ELISA	Mouse
Sitaram RT, Mallikarjuna P, Landstrom M, Ljungberg B. Transforming growth factor-beta promotes aggressiveness and invasion of clear cell renal cell carcinoma. Oncotarget. 2016-05-04 [PMID: 27166254] (WB, Human)	WB	Human
Lee Ji-Hye, Oh Mee-Hye, Park Jae-Seok et al. Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis. Korean J Intern Med. 2014-02-27 [PMID: 24648800] (Human)		Human
Longchamp A, Alonso F, Dubuis C et al. The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins. Biomaterials 2014-03-01 [PMID: 24429385] (WB, Human)	WB	Human
Liao YC, Wang YS, Guo YC et al. Let-7g improves multiple endothelial functions through targeting TGF-beta and SIRT-1 signaling. J Am Coll Cardiol. 2013-11-14 [PMID: 24291274] (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Dubuis C, May L, Alonso F et al. Atorvastatin-Loaded Hydrogel Affects theSmooth Muscle Cells of Human Veins. J Pharmacol Exp Ther. 2013-09-26 [PMID: 24071735] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Berard X, Deglise S, Alonso F et al. Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins. J Vasc Surg 2013-01-23 [PMID: 23351647] (WB, Human)	WB	Human
Cao Y, Szabolcs A, Dutta SK et al. Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. J Biol Chem 2010-10-08 [PMID: 20675371] (WB, Human)	WB	Human
Show All 32 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Shinford Sun	WB	Human	04/25/2024	View Summary Application Western Blot Sample Tested fibroblasts Species Human Lot C-5
Enlarge	5 reviewed by: Pramod Mallikarjuna	WB	Human	11/26/2015	View Summary Application Western Blot Sample Tested HEK 293 cell line vs. HEK 293 cell line treated with TGF-beta Species Human
Enlarge	4 reviewed by: Pramod Mallikarjuna	WB	Human	06/24/2014	View Summary Application Western Blot Sample Tested Renal Cell Carcinoma tissues Species Human

Array NBP1-19773

• Serpin E1/PAI-1 Antibodies
• Serpin E1/PAI-1 Antibody Pair
• Serpin E1/PAI-1 ELISA Kits
• Serpin E1/PAI-1 Lysate
• Serpin E1/PAI-1 Proteins
• Serpin E1/PAI-1 ELISAs
• Serpin E1/PAI-1 Proteins and Enzyme