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SerpinB2 Antibody (930109) [Unconjugated]

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Western blot shows lysates of U937 human histiocytic lymphoma cell line untreated (-) or treated (+) with PMA and HEK001 human epidermal keratinocyte cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Serpin B2 Monoclonal Antibody (Catalog # MAB8550) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Serpin B2 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Western blot shows lysates of U937 human histiocytic lymphoma cell line untreated (-) or treated (+) with PMA and HEK001 human epidermal keratinocyte cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human ...read more
U937 human histiocytic lymphoma cell line either untreated (upper panel) or treated with PMA and Calcium Ionomycin for 2 days (lower panel) was stained with Mouse Anti-Human Serpin B2 Monoclonal Antibody (Catalog # ...read more
Serpin B2 was detected in immersion fixed U937 human histiocytic lymphoma cell line stimulated with PMA using Mouse Anti-Human Serpin B2 Monoclonal Antibody (Catalog # MAB8550) at 25 µg/mL for 3 hours at room ...read more
Genetic Strategies: Serpin B2 was detected in immersion fixed K562 human chronic myelogenous leukemia cell line treated with PMA but is not detected in Serpin B2 knockout (KO) K562 cell line using Mouse ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready, ICC/IF, KO
Clone
930109
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Validated by:
     

Genetic Strategies

    

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB8550U-100UG
Alexa Fluor 405
FAB8550V-100UG
Alexa Fluor 488
FAB8550G-100UG
Alexa Fluor 532
FAB8550X
Alexa Fluor 594
FAB8550T-100UG
Alexa Fluor 647
FAB8550R-100UG
Alexa Fluor 700
FAB8550N-100UG
Alexa Fluor 750
FAB8550S-100UG
Allophycocyanin
FAB8550A
Allophycocyanin/Cy7
FAB8550APCCY7
Biotin
FAB8550B
CoraFluor 1
FAB8550CL1
DyLight 350
FAB8550D
DyLight 405
FAB8550E
DyLight 488
FAB8550K
DyLight 550
FAB8550L
DyLight 594
FAB8550M
DyLight 650
FAB8550W
DyLight 680
FAB8550Y
DyLight 755
FAB8550Z
FITC
FAB8550F
HRP
FAB8550H
Janelia Fluor 525
FAB8550JF525
Janelia Fluor 549
FAB8550I
Janelia Fluor 585
FAB8550JF585
Janelia Fluor 635
FAB8550JF635
Janelia Fluor 646
FAB8550J
Janelia Fluor 669
FAB8550JF669
PE
FAB8550P
PE/Atto594
FAB8550PEATT594
PE/Cy5.5
FAB8550PECY55
PE/Cy7
FAB8550PECY7
PerCP
FAB8550C
mFluor Violet 450 SE
FAB8550MFV450
mFluor Violet 500 SE
FAB8550MFV500
mFluor Violet 610 SE
FAB8550MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB8550-SP
Carrier Free
FAB8550V-100UG
Carrier Free
FAB8550U-100UG
Carrier Free
FAB8550T-100UG
Carrier Free
FAB8550S-100UG
Carrier Free
FAB8550R-100UG
Carrier Free
FAB8550N-100UG
Carrier Free
FAB8550G-100UG
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SerpinB2 Antibody (930109) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human Serpin B2
Glu2-Ala65, Ala99-Pro415
Accession # P05120
Specificity
Detects human Serpin B2 in direct ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
SERPINB2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunocytochemistry 8-25 ug/mL
  • Knockout Validated
  • Western Blot 2 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SerpinB2 Antibody (930109) [Unconjugated]

  • HsT1201
  • Monocyte Arg-serpin
  • PAI
  • PAI2
  • PAI2Urokinase inhibitor
  • Placental plasminogen activator inhibitor
  • PLANH2
  • PLANH2PAI-2
  • plasminogen activator inhibitor 2
  • plasminogen activator inhibitor, type II (arginine-serpin)
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
  • Serpin B2
  • serpin peptidase inhibitor, clade B (ovalbumin), member 2
  • Urokinase Inhibitor

Background

Serpin B2, also known as Plasminogen Activator Inhibitor 2 (PAI-2), is a 415 amino acid serine-type endopeptidase inhibitor with high expression in blood, vasculature and placenta. Its expression is upregulated in pregnancy and in activated monocytes/macrophages by a wide range of viral, bacterial and parasitic agents. Serpin B2 is upregulated in monocytes from HIV-1 infected patients, and is thought to modulate Th1/Th2 responses. Serpin B2/PAI-2 colocalizes with CHL1 and Vitronectin and mediates neurite outgrowth during post-natal brain development. Inhibition of uPA by SerpinB2 in tumors is associated with a favorable prognosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SERPINB2
Uniprot