Synaptopodin Antibody (918842) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Synaptopodin is a 929 amino acid, actin associated protein with restricted expression in brain and kidney.  First reported in glomerular podocytes, the protein is also  found in postsynaptic densities (PSDs) in a subpopulation of telencephalic neurons where it is thought to participate in synaptic plasticity in dendritic spines.  Despite its localization in PSDs, it is not homologous to other PSD proteins.  Loss of synaptopodin expression has been demonstrated in Alzheimer’s patients. In glomeruli, synaptopodin localizes to the cytoplasm of podocyte foot processes. 

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC/IF, IHC.

Showing Publications 1 - 6 of 6.

Publications using MAB8977	Applications	Species
Meliambro K, Yang Y, de Cos M et al. KIBRA upregulation increases susceptibility to glomerular injury and correlates with kidney function decline JCI insight 2023-02-28 [PMID: 36853804]
ZJ Sun, DY Chang, M Chen, MH Zhao Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease JCI Insight, 2022-12-22;7(24):. 2022-12-22 [PMID: 36546481] (IHC, Mouse)	IHC	Mouse
Rui-Xue Wang, Liang Wu, Su-Fang Chen, Zhi-Ying Li, Ming-Hui Zhao, Min Chen Renal Expression of Annexin A1 Is Associated With the Severity of Renal Injury in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis Frontiers in Medicine 2022-06-17 [PMID: 35783659]
LY Wang, XJ Sun, M Chen, MH Zhao The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis J Transl Med, 2019-06-11;17(1):197. 2019-06-11 [PMID: 31186034] (ICC/IF, Human)	ICC/IF	Human
F Zhong, Z Chen, L Zhang, Y Xie, V Nair, W Ju, M Kretzler, RG Nelson, Z Li, H Chen, Y Wang, A Zhang, K Lee, Z Liu, JC He Tyro3 is a podocyte protective factor in glomerular disease JCI Insight, 2018-11-15;3(22):. 2018-11-15 [PMID: 30429374] (IHC, Human)	IHC	Human
WJ Liu, ZH Li, XC Chen, XL Zhao, Z Zhong, C Yang, HL Wu, N An, WY Li, HF Liu Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy Sci Rep, 2017-08-17;7(1):8643. 2017-08-17 [PMID: 28819100] (IHC, Human)	IHC	Human

Array MAB8977

• Synaptopodin Antibodies
• Synaptopodin ELISA Kit
• Synaptopodin Proteins