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SOX2 Antibody (245610) [Phycoerythrin]

 (10 Publications)
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NTera-2 human testicular embryonic carcinoma cell line was stained with Mouse Anti-Human/Mouse SOX2 PE-conjugated Monoclonal Antibody (Catalog # IC2018P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.
NTera-2 human testicular embryonic carcinoma cell line was stained with Mouse Anti-Human/Mouse SOX2 PE-conjugated Monoclonal Antibody (Catalog # IC2018P, filled histogram) or isotype control antibody (Catalog # IC003P, ...read more
(a) RT-PCR analysis of SOX2 expression normalized to GAPDH in human tissues. BM from MM patients (n = 25), healthy donors (n = 15), myeloma cell lines (n = 10), and 20 human tissues (n = 1) was screened for SOX2 ...read more
Pluripotency of Monkey ESCs grown under the MT-fCFA culture condition.A. Immunocytochemical analyses show that CMK6SFF cells (P33) have a characteristic expression pattern of typical pluripotency factors, Nanog, Oct4, ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow
Clone
245610
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC2018U-100UG
Alexa Fluor 405
IC2018V-100UG
Alexa Fluor 488
IC2018G
Alexa Fluor 532
FAB2018X
Alexa Fluor 594
IC2018T-100UG
Alexa Fluor 647
IC2018R-100UG
Alexa Fluor 700
IC2018N-100UG
Alexa Fluor 750
IC2018S-100UG
Allophycocyanin
IC2018A
Biotin
FAB2018B
CoraFluor 1
FAB2018CL1
DyLight 350
FAB2018D
DyLight 405
FAB2018E
DyLight 488
FAB2018K
DyLight 550
FAB2018L
DyLight 594
FAB2018M
DyLight 650
FAB2018W
DyLight 680
FAB2018Y
DyLight 755
FAB2018Z
FITC
FAB2018F
HRP
FAB2018H
Janelia Fluor 525
FAB2018JF525
Janelia Fluor 549
FAB2018I
Janelia Fluor 585
FAB2018JF585
Janelia Fluor 635
FAB2018JF635
Janelia Fluor 646
FAB2018J
Janelia Fluor 669
FAB2018JF669
Phycoerythrin
IC2018P-025
Unconjugated
MAB2018
mFluor Violet 450 SE
FAB2018MFV450
mFluor Violet 500 SE
FAB2018MFV500
mFluor Violet 610 SE
FAB2018MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2018
Carrier Free
MAB2018
Carrier Free
IC2018A
Carrier Free
IC2018G
Carrier Free
MAB2018-SP
Carrier Free
IC2018P-025
Carrier Free
IC2018V-100UG
Carrier Free
IC2018U-100UG
Carrier Free
IC2018T-100UG
Carrier Free
IC2018S-100UG
Carrier Free
IC2018R-100UG
Carrier Free
IC2018N-100UG
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SOX2 Antibody (245610) [Phycoerythrin] Summary

Immunogen
E. coli-derived recombinant human SOX2
Gly135-Met317
Accession # P48431
Specificity
Detects human and mouse SOX2 in Western blots.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
SOX2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
IC2018P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX2 Antibody (245610) [Phycoerythrin]

  • ANOP3
  • MCOPS3
  • MGC2413
  • SOX2
  • SRY (sex determining region Y)-box 2
  • SRY-related HMG-box gene 2
  • transcription factor SOX2
  • transcription factor SOX-2

Background

SOX2 belongs to the SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX2 functions in specifying the first three lineages present at implantation and in regulating proliferation and differentiation in the developing peripheral nervous system (1-6).
  1. Graham, V. et al. (2003) Neuron 39:749.
  2. Avilion, A.A. et al. (2003) Genes Dev. 17:126.
  3. Kishi, M. et al. (2000) Development 127:791.
  4. Yuan, H. et al. (1995) Genes Dev. 9:2635.
  5. Uwanogho, D. et al. (1995) Mech. Dev. 49:23.
  6. Stevanovic, M. (2003) Mol. Biol. Rep. 30:127.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SOX2 Antibody
(245610) [Phycoerythr
IC2018P
SOX2 Antibody (245610) [Phycoerythrin]
Species: Hu, Mu
Applications: Flow

Publications for SOX2 Antibody (IC2018P)(10)

We have publications tested in 2 confirmed species: Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).

We have publications tested in 1 application: Flow Cytometry.


Filter By Application
Flow Cytometry
(8)
All Applications
Filter By Species
Human
(7)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(1)
All Species
Showing Publications 1 - 10 of 10.
Publications using IC2018P Applications Species
Aref, S;Khaled, O;Menshawy, NE;Azmy, E;Aref, M;Salama, O;Khaled, N; Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia Journal of the Egyptian National Cancer Institute 2024-02-12 [PMID: 38342816] (Flow Cytometry, Human) Flow Cytometry Human
Michaela Tencerova, Lilli Lundby, Steen Buntzen, Stig Norderval, Helene Tarri Hougaard, Bodil Ginnerup Pedersen et al. Molecular differences of adipose-derived mesenchymal stem cells between non-responders and responders in treatment of transphincteric perianal fistulas Stem Cell Research & Therapy 12/1/2021 [PMID: 34819138]
N Malerba, P Benzoni, GM Squeo, R Milanesi, F Giannetti, LG Sadleir, G Poke, B Augello, AI Croce, A Barbuti, G Merla Generation of the induced human pluripotent stem cell lines CSSi009-A from a patient with a GNB5 pathogenic variant, and CSSi010-A from a CRISPR/Cas9 engineered GNB5 knock-out human cell line Stem Cell Res, 2019-08-22;40(0):101547. 2019-08-22 [PMID: 31479876] (Flow Cytometry, Human) Flow Cytometry Human
B Ermon, CB Volpato, G Cattelan, R Silipigni, M Di Segni, C Cantaloni, M Casella, PP Pramstalle, G Pompilio, E Sommariva, V Meraviglia, A Rossini Derivation of human induced pluripotent stem cell line EURACi004-A from skin fibroblasts of a patient with Arrhythmogenic Cardiomyopathy carrying the heterozygous PKP2 mutation c.2569_3018del50 Stem Cell Res, 2018-09-06;32(0):78-82. 2018-09-06 [PMID: 30219716] (Flow Cytometry, Human) Flow Cytometry Human
V Meraviglia, P Benzoni, S Landi, C Murano, M Langione, BM Motta, S Baratto, R Silipigni, M Di Segni, PP Pramstalle, D DiFrancesc, E Gazzerro, A Barbuti, A Rossini Generation of human induced pluripotent stem cells (EURACi001-A, EURACi002-A, EURACi003-A) from peripheral blood mononuclear cells of three patients carrying mutations in the CAV3 gene Stem Cell Res, 2017-12-18;27(0):25-29. 2017-12-18 [PMID: 29304398] (Flow Cytometry, Human) Flow Cytometry Human
E Varga, M Hansen, T Wüst, M von Linder, E van den Ak Generation of human erythroblast-derived iPSC line using episomal reprogramming system Stem Cell Res, 2017-10-12;25(0):30-33. 2017-10-12 [PMID: 29040913] (Flow Cytometry, Human) Flow Cytometry Human
Elaine Emmerson, Alison J May, Sara Nathan, Noel Cruz-Pacheco, Carlos O Lizama, Lenka Maliskova et al. SOX2 regulates acinar cell development in the salivary gland eLife 6/17/2017 [PMID: 28623666]
Mitochondrial role in adaptive response to stress conditions in preeclampsia Sci Rep, 2016-08-30;6(0):32410. 2016-08-30 [PMID: 27573305] (Flow Cytometry, Human) Flow Cytometry Human
Ono T, Suzuki Y, Kato Y, Fujita R, Araki T, Yamashita T, Kato H, Torii R, Sato N A single-cell and feeder-free culture system for monkey embryonic stem cells. PLoS ONE, 2014-02-05;9(2):e88346. 2014-02-05 [PMID: 24505480] (Flow Cytometry, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)) Flow Cytometry Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Kobold S, Tams S, Luetkens T, Cao Y, Sezer O, Bartels B, Reinhard H, Templin J, Bartels K, Hildebrandt Y, Lajmi N, Marx A, Haag F, Bokemeyer C, Kroger N, Atanackovic D Patients with multiple myeloma develop SOX2-specific autoantibodies after allogeneic stem cell transplantation. Clin Dev Immunol, 2011-11-15;2011(0):302145. 2011-11-15 [PMID: 22190969] (Flow Cytometry, Human) Flow Cytometry Human

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Secondary Antibodies

 

Isotype Controls

Additional SOX2 Products

Blogs on SOX2. Showing 1-10 of 13 blog posts - Show all blog posts.

Check out the latest blog posts on SOX2.
Spheroids vs. Organoids: Which 3D Cell Culture Model is Best for You?
By Jennifer Jones, M.S.Spheroids and organoids are two words that, like “butter” and “margarine”, are often referred to interchangeably but have distinct meanings. The progression and adopt...  Read full blog post.

  Read full blog post.
Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness
By Jamshed Arslan, Pharm D, PhDBreast cancer is the most common cancer among women that causes the greatest number of cancer-related deaths worldwide. After radiotherapy or cytotoxic chemotherapy like paclitax...  Read full blog post.
Deriving neural precursor cells from human induced pluripotent stem cells
By Jennifer Sokolowski, MD, PhD.Human induced pluripotent stem cells (iPSCs) can be used to create models of human organ systems and are useful for a) ascertaining the mechanisms underlying pathological conditions...  Read full blog post.
Application Focus: New Methods for iPSC Differentiation, Inducing a Mammary Fate
Discovery of the Key to PluripotencyInduced pluripotent stem cells (iPSCs) may be generated from a wide range of fully differentiated cells, and under optimal conditions may be prompted to differentiate into virtu...  Read full blog post.
Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma
By Jamshed Arslan Pharm.D. Multiple myeloma (MM) is a cancer of antibody-producing plasma cells. The bone marrow (BM) of MM patients is hypoxic, and MM cells overexpress many cancerous genes that are regulated by hy...  Read full blog post.
KLF4 as a transcription factor in stem cell differentiation
Kru¨ppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency. KLF4 has specifically been tied to many diverse cellular processes, including sel...  Read full blog post.
SOX2 - a stem cell transcription factor
The SOX gene family encodes a group of highly conserved transcription factors defined by the presence of a conserved high motility group (HMG) DNA-binding domain. They are involved in embryonic development regulation and cell fate determination. Al...  Read full blog post.
SOX2: an Important Stem Cell Transcription Factor
SOX2 is a transcription factor that is expressed by self-renewing and multipotent stem cells of the embryonic neuroepithelium. Sox-2 was found to be expressed by dividing neural progenitor cells. Constitutive expression of SOX2 has also been shown to ...  Read full blog post.
Sox2 and Oct4: Roles in Embryonic Stem Cell Pluripotency
Embryonic stem (ES) cells are cells derived from the inner cell mass of the blastocyst, an early-stage embryo. ES cells are distinguished from other cells due to their pluripotency, which is the ability to differentiate into any different type of cell...  Read full blog post.
Showing 1-10 of 13 blog posts - Show all blog posts.
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Bioinformatics

Gene Symbol SOX2
Uniprot