Sirtuin 1/SIRT1 Antibody

Manufactured by Genomic Antibody Technology™. GAT FAQs

SIRT1 (mammalian homologue of silent information regulator 2), is a NAD-dependent class III deacetylase which belongs to mammalian sirtuin family and generates enzymatic activity in the presence of NAD+. SIRT1 is primarily localized in the nucleus and deacetylates not only histones but also a number of other transcription factors/cofactors, such as p53, FOXO (forkhead), PPAR- gamma coactivator-1 alpha, and NFkB, thus affecting the critical cellular pathways involved in stress response. SIRT1 plays an important role in the energy metabolism by interacting with PPAR-gamma and inhibiting its transcriptional activity towards genes mediating fat storage through docking with its cofactors. SIRT1 also plays an essential function in mediating cellular survival by deacetylating substrates such as FOXO, p53 , DNA repair factor Ku70 and NFkB. SIRT1 has been shown to get upregulated in response to stress-induced cell death, especially upon oxidative stress and calorie restriction, and SIRT1 knockout mice fail to extend lifespan induced by calorie restriction. Moreover, expression of SIRT1 gets increased to promote neuronal survival in Alzheimer's disease model as well as in primary neurons subjected to neurotoxic insult.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Simple Western.

Showing Publication 1 - 1 of 1.

Publication using NBP1-49540	Applications	Species
Yanes R, Zhang H, Shen Y et al. Metabolic reprogramming in memory CD4 T cell responses of old adults Clinical Immunology 2019-07-01 [PMID: 31279855] (Simple Western, Human)	Simple Western	Human

Array NBP1-49540

• Sirtuin 1/SIRT1 Antibodies
• Sirtuin 1/SIRT1 ELISA Kits
• Sirtuin 1/SIRT1 Kit
• Sirtuin 1/SIRT1 Lysate
• Sirtuin 1/SIRT1 Proteins
• Sirtuin 1/SIRT1 Proteins and Enzyme