SF3B2 Antibody

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 6 of 6.

Publications using NB100-79848	Applications	Species
Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Taiping Chen, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yang Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing Nature Communications 2024-04-01 [PMID: 38561334]
Harms FL, Dingemans AJM, Hempel M et al. de novo PHF5A variants are associated with craniofacial abnormalities, developmental delay, and hypospadias Genetics in medicine : official journal of the American College of Medical Genetics 2023-07-06 [PMID: 37422718]
von Elsner L, Chai G, Schneeberger PE Et al. Biallelic FRA10AC1 variants cause a neurodevelopmental disorder with growth retardation Brain : a journal of neurology 2021-10-25 [PMID: 34694367]
Murthy T, Bluemn T, Gupta A et al. Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin J. Biol. Chem. 2018-05-15 [PMID: 29764937] (Human)		Human
Zheng YZ, Xue MZ, Shen HJ et al. PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression. Cancer Res 2018-06-15 [PMID: 29700004]
Yang Y, Hadjikyriacou A, Xia Z et al. PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145 Nat Commun 2015-03-04 [PMID: 25737013] (WB, IP, Human)	WB, IP	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Astrid Spannhoff	WB	Human	11/19/2010	View Summary Application Western Blot Sample Tested Hela whole cell lysate, Sample Amount: 15-20 ul Species Human

Array NB100-79848

• SF3B2 Antibodies
• SF3B2 Lysate
• SF3B2 Proteins