ASXL1 Antibody (6E2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. Although the function of the protein encoded by this gene is not known, it does show some sequence similarity to the protein encoded by the Drosophila Asx gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 3 of 3.

Publications using H00171023-M05	Applications	Species
Valletta S, Dolatshad H, Bartenstein M et al. ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts. Oncotarget 2015-12-29 [PMID: 26623729] (WB)	WB
Ismail IH, Davidson R, Gagne JP et al. Germ-line Mutations in BAP1 Impair its Function in DNA Double-Strand break Repair. Cancer Res. 2014-06-03 [PMID: 24894717] (IP, WB, Human) Details: U2OS cells were transfected with control/ASXL1 shRNA for 48 h and the nuclear extracts were processed for WB using ASXL1 and BAP1 antibodies. In another set of experiment, U2OS cells were exposed or not to radiation (6 Gy) followed by recovery for 2 hr and the nuclear extracts were processed for immunoprecipitation using BAP1 or ASXL1 antibodies followed by WB of flow through (FT) and elute (El) and 20% of the input (Supplementary Figure 2 C and D).	IP, WB	Human
Davies C, Yip BH, Fernandez-Mercado M et al. Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34(+) progenitor cells. Br J Haematol. 2013-01-08 [PMID: 23294243]

Array H00171023-M05

• ASXL1 Antibodies
• ASXL1 Lysates
• ASXL1 Protein