SDHB Antibody - BSA Free

Manufactured by Genomic Antibody Technology™. GAT FAQs

SDHB [Succinate dehydrogenase (ubiquinone) iron-sulfur subunit, mitochondrial] is an iron-sulfur protein subunit of succinate dehydrogenase (SDH) which is involved in mitochondrial electron transport chain's complex II and is accountable for electrons transfer from succinate to ubiquinone/coenzyme Q. The complex II is a key respiratory enzyme which links Krebs cycle and electron transport chain, and is composed of four subunits: the flavoprotein SDHA, iron-sulfur protein SDHB, and a cytochrome b560 composed of SDHC and SDHD as well as additional groups such as iron-sulphur centres and ubiquinone. SDH complex functions as a tumour suppressor, and loss of any of the subunit proteins leads to destabilization of the complex that follows carcinogenesis. Defects in SDHB have also been linked to susceptibility to pheochromocytoma (PCC), paragangliomas type 4 (PGL4), paraganglioma and gastric stromal sarcoma (PGGSS), and Cowden-like syndrome (CWDLS).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-54154	Applications	Species
VAsquez-Trincado C, Patel M, Sivaramakrishnan A et al. Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation Human molecular genetics 2021-09-22 [PMID: 34550363]
Sikorski K, Mehta A et al. A high-throughput pipeline for validation of antibodies. Nat Methods 2018-01-11 [PMID: 30377371] (Human) Details: Antibody validation based on denaturing gel electrophoresis of biotinylated cell lysates (PAGE) followed by mass spectrometry (MS) and antibody array analysis (MAP).		Human
Morton NM, Beltram J, Carter RN et al. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat. Med. 2016-06-06 [PMID: 27270587]
Salem AF, Howell A, Sartini M. Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1 alpha, autophagy and ketone body production. Cell Cycle. 2012-11-01 [PMID: 23047605] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	WB	Other	11/17/2014	View Summary Application Western Blot Sample Tested Whole Skeletal Muscle Lysate or Purified Mitochondria Species Other Lot A-1

Array NBP1-54154

• SDHB Antibodies
• SDHB Lysate
• SDHB Proteins