Recombinant Human TrkA Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TrkA, the product of the proto-oncogene trk, is a member of the neurotrophic tyrosine kinase receptor family that has three members. TrkA, Trk B and Trk C preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Two distinct TrkA isoforms that differ by virtue of a 6-amino acid insertion in their extracellular domain have been identified. The longer TrkA isoform is the only isoform expressed within neuronal tissues whereas the shorter TrkA is expressed mainly in non-neuronal tissues. NGF binds to TrkA with low affinity and activates its cytoplasmic kinase, initiating a signaling cascade that mediates neuronal survival and differentiation. Higher affinity binding of NGF requires the coexpression of TrkA with the p75 NGF receptor (NGFR), a member of the tumor necrosis factor receptor superfamily. NGFR binds all neurotrophins with low affinity and modulates Trk activity as well as alters the specificity of Trk receptors for their ligands. NGFR can also mediate cell death when expressed independent of Trk.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Bacteria.

We have publications tested in 5 applications: Bioassay, ELISA (Capture), In Vivo, PcIP, Surface Plasmon Resonance.

Showing Publications 1 - 8 of 8.

Publications using 175-TK	Applications	Species
AJ Poole, L Frigotto, ME Smith, C Baar, G Ivanova-Be, A Jaulent, C Stace, CG Ullman, AV Hine A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics Sci Rep, 2019-01-30;9(1):930. 2019-01-30 [PMID: 30700786] (ELISA (Capture), Human)	ELISA (Capture)	Human
JM Hall, F Gomez-Pini, LM Savage Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function Front Neurosci, 2018-11-01;12(0):773. 2018-11-01 [PMID: 30443202] (In Vivo, Rat)	In Vivo	Rat
JI Hurtado-Za, B Ramachandr, S Ahmed, R Halder, C Bolleyer, A Awasthi, MA Stahlberg, RJ Wagener, K Anderson, RM Drenan, HA Lester, JM Miwa, JF Staiger, A Fischer, C Dean TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus Nat Commun, 2017-07-19;8(0):15878. 2017-07-19 [PMID: 28722015] (Bioassay, Mouse)	Bioassay	Mouse
JN Sleigh, JM Dawes, SJ West, N Wei, EL Spaulding, A Gómez-Mart, Q Zhang, RW Burgess, MZ Cader, K Talbot, XL Yang, DL Bennett, G Schiavo Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations Proc. Natl. Acad. Sci. U.S.A, 2017-03-28;0(0):. 2017-03-28 [PMID: 28351971] (Bioassay)	Bioassay
Prencipe G, Minnone G, Strippoli R, De Pasquale L, Petrini S, Caiello I, Manni L, De Benedetti F, Bracci-Laudiero L Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J Immunol, 2014-02-28;192(7):3345-54. 2014-02-28 [PMID: 24585880] (Bioassay, Human)	Bioassay	Human
Tsai CY, Chan JY, Hsu KS Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS ONE, 2012-03-19;7(3):e33527. 2012-03-19 [PMID: 22442695] (In Vivo, Rat)	In Vivo	Rat
Vaegter CB, Jansen P, Fjorback AW Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat. Neurosci., 2010-11-21;14(1):54-61. 2010-11-21 [PMID: 21102451] (Surface Plasmon Resonance)	Surface Plasmon Resonance
Lu B, PereiraPerrin M A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect. Immun., 2008-06-09;76(8):3530-8. 2008-06-09 [PMID: 18541656] (PcIP, Bacteria)	PcIP	Bacteria

Array 175-TK

• TrkA Antibodies
• TrkA Antibody Pair
• TrkA ELISA Kit
• TrkA Lysates
• TrkA Protein
• TrkA ELISA
• TrkA Proteins and Enzymes