POT1 Antibody

POT1 (protection of telomeres protein 1), a member of telombin family, is expressed ubiquitously and localizes to nucleus/chromosomal telomeres. It forms a component of telomerase RNP (ribonucleoprotein) complex which is essential for chromosome termini replication. POT1 participates in shelterin complex/telosome (contains TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 - regulates telomeric length alongwith protecting telomers), telomerase holoenzyme complex (TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and TERC) and is also found complexed with TERF1, TINF2 and TNKS1. POT1 interacts with TNKS1 and can heterodimerize with ACD for enhancing telomere elongation via increase in telomerase processivity. POT1 implicates in double-stranded telomeric DNA-binding TRF1 complex which is essential to the regulation of telomere length by cis-inhibition of telomerase. POT1 acts as a single-stranded telomeric DNA-binding protein and thus behaves as a downstream effector of TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. POT1 functional alterations can lead to G-strand overhang loss, chromosomal-end fusions, chromosomal rearrangements, and rapid cell cycle arrest, ultimately leading to senescence and apoptosis. Accordingly, POT1 expression is altered in tumors and is specifically upregulated in therapeutic/radiation-resistant cancer cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using NB500-176	Applications	Species
Hou J, Yun Y, Jeon B et al. Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence Int J Mol Sci 2023-09-19 [PMID: 37762556]
Zeng J, Hills SA, Ozono E, Diffley JFX Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication Cell 2023-01-19 [PMID: 36681079] (WB, Human)	WB	Human
Chen L, Zhang C, Ma W et al. METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability Nucleic acids research 2022-11-18 [PMID: 36399511] (WB, Human) Details: Dilution used in WB 1:1000	WB	Human
A Lanna, B Vaz, C D'Ambra, S Valvo, C Vuotto, V Chiurchiù, O Devine, M Sanchez, G Borsellino, AN Akbar, M De Bardi, DW Gilroy, ML Dustin, B Blumer, M Karin An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory Nature Cell Biology, 2022-09-15;0(0):. 2022-09-15 [PMID: 36109671]
Yu EY, Zahid SS, Aloe S Et al. Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology Communications biology 2021-11-19 [PMID: 34799676] (WB, Human)	WB	Human
Li X, Li X, Xie C Et al. cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence Protein & cell 2021-10-22 [PMID: 34676498] (Chemotaxis, Human)	Chemotaxis	Human
Li T, Lin S, Li C et al. MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence Aging (Albany NY) 2020-07-18 [PMID: 32687062] (WB, Human)	WB	Human
Wu S, Ge Y, Li X et al. BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1 PLoS Genet. 2020-06-01 [PMID: 32502208] (WB, Human)	WB	Human
Swanson MJ, Baribault ME, Israel JN, Bae NS Telomere protein RAP1 levels are affected by cellular aging and oxidative stress. Biomed Rep 2016-08-01 [PMID: 27446538] (WB)	WB
Sishc BJ, Nelson CB, McKenna MJ et al. Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis. Front Oncol 2015-11-24 [PMID: 26636039] (WB)	WB
Ci X, Li B, Ma X et al. Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget 2015-11-10 [PMID: 26472030] (WB)	WB
Luo Z, Feng X, Wang H et al. Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression. Aging Cell. 2015-03-06 [PMID: 25753893] (WB, Human)	WB	Human
Wojdyla L, Stone AL, Sethakorn N et al. T-oligo as an anticancer agent in colorectal cancer. Biochem. Biophys. Res. Commun. 2014-03-12 [PMID: 24632202] (WB, Human)	WB	Human
Kamranvar SA, Chen X, Masucci MG. Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus. Oncogene. 2013-05-27 [PMID: 23708666] (WB, Human)	WB	Human
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response Nucleic Acids Res 2012-11-27 [PMID: 23193277] (WB, Human)	WB	Human
Yang Q, Zhang R, Horikawa I et al. Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence. Cancer Res 2007-12-01 [PMID: 18089797]
Chen LY, Liu D, Songyang Z et al. Telomere maintenance through spatial control of telomeric proteins. Mol Cell Biol 2007-08-01 [PMID: 17562870] (WB, Human)	WB	Human
Show All 17 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	09/23/2009	View Summary Application Western Blot Sample Tested Human lympoblast cells, Sample Amount: 35 ug Species Human

Array NB500-176

• POT1 Antibodies
• POT1 ELISA Kits
• POT1 Lysate
• POT1 Proteins