TEM8/ANTXR1 Antibody (200C1339(SB20)) - BSA Free

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). Based on TEM8s interaction with the C5 domain of collagen a3(VI), a protein also preferentially expressed in tumor endothelium, it is thought that TEM8 plays an important role in tumor angiogenesis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: FLOW, ICC/IF, IHC-P, WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-56585	Applications	Species
Kieffer Y, Hocine HR, Gentric G et al. Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer Cancer Discov 2020-05-20 [PMID: 32434947] (FLOW, Human)	FLOW	Human
Matsuda K, Ohga N, Hida Y et al. Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Commun. 2010-04-16 [PMID: 20302845] (ICC/IF, Human) Details: IF/ICC: primary human xenograft tumor endothelial cell cultures (Fig 2B).	ICC/IF	Human
Werner E, Kowalczyk AP, Faundez V. Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton. J Biol Chem. 2006-08-11 [PMID: 16762926] (WB) Details: WB: TEM8 transfected/non-transfected 293 cells (Figs 1A, 4A, and 5D). Note: antibody specificity is validated by using TEM8 transfected/non-transfected 293 cells in Figs 1A and 4A.	WB
Hotchkiss KA, Basile CM, Spring SC et al. TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen. Exp Cell Res. 2005-04-15 [PMID: 15777794] (WB, IHC-P, Human) Details: IHC (Paraffin): Fig 1A (human umbilical cords); WB: Fig 1C and 1D [human venous epithelial cells (HUVEC)].	WB, IHC-P	Human
Nanda A, Carson-Walter EB, Seaman S et al. TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). Cancer Res. 2004-02-01 [PMID: 14871805] (WB, Human) Details: WB: TEM8 transfected/non-transfected 293 cells (Fig 1A and B), human colon cancer tissue lysates and patient-matched normal colonic mucosa transfected (Fig 1C). Note: antibody specificity is validated by using TEM8 transfected/non-transfected 293 cells in	WB	Human

Array NB100-56585

• TEM8/ANTXR1 Antibodies
• TEM8/ANTXR1 Lysates
• TEM8/ANTXR1 Proteins
• TEM8/ANTXR1 Proteins and Enzymes