Name: Histone H2AX [p Ser139] Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF2288
Price: 399 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, IHC, ICC/IF
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Phosphopeptide containing human Histone H2AX S139 site
Modification	p Ser139
Specificity	Detects human Histone H2AX when phosphorylated at S139.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	H2AFX
Purity Statement	Antigen and protein A Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF2288	Applications	Species
Zhuo, H;Hou, J;Hong, Z;Yu, S;Peng, H;Zhang, L;Xie, W;Hong, X; TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer Cell death & disease 2024-08-21 [PMID: 39168971] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Huang, HY;Chen, CH;Cheng, FJ;Wang, BW;Tu, CY;Chen, YJ;He, YH;Yao, CH;Huang, WC; Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer Journal of hazardous materials 2024-07-10 [PMID: 39047551] (Western Blot, Human)	Western Blot	Human
Nataliya, B;Mikhail, A;Vladimir, P;Olga, G;Maksim, V;Ivan, Z;Ekaterina, N;Georgy, S;Natalia, D;Pavel, M;Andrey, C;Maria, S;Maxim, K;Anastasiya, T;Uliana, D;Zhanna, A;Vsevolod, T;Natalia, K;Anastasiya, E; Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer Experimental & molecular medicine 2023-07-03 [PMID: 37394579] (Western Blot, Human)	Western Blot	Human
DM Zhang, R Navara, T Yin, J Szymanski, U Goldsztejn, C Kenkel, A Lang, C Mpoy, CE Lipovsky, Y Qiao, S Hicks, G Li, KMS Moore, C Bergom, BE Rogers, CG Robinson, PS Cuculich, JK Schwarz, SL Rentschler Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis Nature Communications, 2021-09-24;12(1):5558. 2021-09-24 [PMID: 34561429] (IHC, Mouse)	IHC	Mouse
M Al-Mugotir, JJ Lovelace, J George, M Bessho, D Pal, L Struble, C Kolar, S Rana, A Natarajan, T Bessho, GEO Borgstahl Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction PLoS ONE, 2021-03-30;16(3):e0248941. 2021-03-30 [PMID: 33784323] (Western Blot, Human)	Western Blot	Human
Yuli T. Magalhaes, Gisele E. T. Silva, Juliana H. Osaki, Clarissa R. R. Rocha, Fabio L. Forti RHOAming Through the Nucleotide Excision Repair Pathway as a Mechanism of Cellular Response Against the Effects of UV Radiation Frontiers in Cell and Developmental Biology 8/19/2020 [PMID: 33015036]
A Schepsky, G Asta Traus, J Petur Joel, S Ingthorsso, J Kricker, J Thor Bergt, A Asbjarnars, T Gudjonsson, N Nupponen, A Slipicevic, F Lehmann, T Gudjonsson Melflufen, a peptide-conjugated alkylator, is an efficient anti-neo-plastic drug in breast cancer cell lines Cancer Med, 2020-07-27;0(0):. 2020-07-27 [PMID: 32717133] (ICC, Human)	ICC	Human
CE Hellweg, V Shinde, SP Srinivasan, M Henry, T Rotshteyn, C Baumstark-, C Schmitz, S Feles, LF Spitta, R Hemmersbac, J Hescheler, A Sachinidis Radiation Response of Murine Embryonic Stem Cells Cells, 2020-07-09;9(7):. 2020-07-09 [PMID: 32660081] (ICC, Mouse)	ICC	Mouse
S Miranda, M Correia, AG Dias, A Pestana, P Soares, J Nunes, J Lima, V Máximo, P Boaventura Evaluation of the role of mitochondria in the non-targeted effects of ionizing radiation using cybrid cellular models Sci Rep, 2020-04-09;10(1):6131. 2020-04-09 [PMID: 32273537] (ICC, Human)	ICC	Human
HL Li, CY Wang, J Fu, XJ Yang, Y Sun, YH Shao, LH Zhang, XM Yang, XL Zhang, J Lin PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity Eur Rev Med Pharmacol Sci, 2019-12-01;23(23):10453-10458. 2019-12-01 [PMID: 31841199] (ICC, Human)	ICC	Human
Y Wang, AJ Bernhardy, J Nacson, JJ Krais, YF Tan, E Nicolas, MR Radke, E Handorf, A Llop-Gueva, J Balmaña, EM Swisher, V Serra, S Peri, N Johnson BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance Nat Commun, 2019-12-11;10(1):5661. 2019-12-11 [PMID: 31827092] (ICC, Human)	ICC	Human
Z Simandi, K Pajer, K Karolyi, T Sieler, LL Jiang, Z Kolostyak, Z Sari, Z Fekecs, A Pap, A Patsalos, GA Contreras, B Reho, Z Papp, X Guo, A Horvath, G Kiss, Z Keresztess, G Vámosi, J Hickman, H Xu, D Dormann, T Hortobagyi, M Antal, A Nogradi, L Nagy Arginine methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons J. Neurosci., 2018-07-27;0(0):. 2018-07-27 [PMID: 30054395] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed et al. C9orf72 expansion disrupts ATM-mediated chromosomal break repair Nature Neuroscience 9/1/2017 [PMID: 28714954]
M Jangi, C Fleet, P Cullen, SV Gupta, S Mekhoubad, E Chiao, N Allaire, CF Bennett, F Rigo, AR Krainer, JA Hurt, JP Carulli, JF Staropoli SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;0(0):. 2017-03-07 [PMID: 28270613] (IHC, Mouse)	IHC	Mouse
Jianmin Wu, Yimin Sun, Pei-Ying Zhang, Mengyao Qian, Hengchao Zhang, Xiao Chen et al. The Fra-1–miR-134–SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells Cell Death & Disease 9/29/2016 [PMID: 27685628]
N Rebolleda, I Losada-Fer, G Perez-Chac, R Castejon, S Rosado, M Morado, MT Vallejo-Cr, A Martinez, JA Vargas-Nuñ, P Perez-Acie Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model PLoS ONE, 2016-04-21;11(4):e0154159. 2016-04-21 [PMID: 27101369] (Western Blot, Human)	Western Blot	Human
Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez-Villasenor I, Heath P, Romero I, Ince P, Wharton S Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain, 2015-08-22;8(0):51. 2015-08-22 [PMID: 26297026]
Kim , Bo S, Serebreni , Leonid, Fallica , Jonathan, Hamdan , Omar, Wang , Lan, Johnston , Laura, Kolb , Todd, Damarla , Mahendra, Damico , Rachel, Hassoun , Paul M Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. PLoS ONE, 2015-04-01;10(4):e0124189. 2015-04-01 [PMID: 25831123] (Western Blot, Rat)	Western Blot	Rat
Susumu Ohshima Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes Oxidative Medicine and Cellular Longevity 10/3/2012 [PMID: 23091651]
Adeyemi RO, Landry S, Davis ME et al. Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog 1/1/2010 [PMID: 20949077]
Jia XZ, Yang SY, Zhou J, Li SY, Ni JH, An GS, Jia HT Inhibition of CHK1 kinase by Go6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells. Biochem. Pharmacol., 2008-11-18;77(5):770-80. 2008-11-18 [PMID: 19059218] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Yang SY, Jia XZ, Feng LY, Li SY, An GS, Ni JH, Jia HT Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells. Biochem. Pharmacol., 2008-10-28;77(3):433-43. 2008-10-28 [PMID: 19014910] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Roh DS, Cook AL, Rhee SS, Joshi A, Kowalski R, Dhaliwal DK, Funderburgh JL DNA cross-linking, double-strand breaks, and apoptosis in corneal endothelial cells after a single exposure to mitomycin C. Invest. Ophthalmol. Vis. Sci., 2008-07-24;49(11):4837-43. 2008-07-24 [PMID: 18658091] (ICC, Goat)	ICC	Goat
Tang KF, He CX, Zeng GL, Wu J, Song GB, Shi YS, Zhang WG, Huang AL, Steinle A, Ren H Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine. Biochem. Biophys. Res. Commun., 2008-04-04;370(4):578-83. 2008-04-04 [PMID: 18395517] (ICC, Human)	ICC	Human
Bogliolo M, Lyakhovich A, Callen E, Castella M, Cappelli E, Ramirez MJ, Creus A, Marcos R, Kalb R, Neveling K, Schindler D, Surralles J Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J., 2007-02-15;26(5):1340-51. 2007-02-15 [PMID: 17304220] (ICC, Human)	ICC	Human
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Histone H2AX [p Ser139] Antibody [Unconjugated]

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Carrier Free AF2288-SP