TERF2IP Antibody

Mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TERF21P have no recognized orthologs in budding yeast. However, human Rap1 (hRap1) is an ortholog of the yeast telomeric protein, scRap1p. hRap1 is a homodimer, has three conserved sequence motifs in common with scRap1, is located at telomeres, and plays a role in telomere length regulation. Although scRap1 binds telomeric DNA directly, TERF21P is recruited to telomeres by TERF21P and binds it with its C-terminus, rather than directly binding DNA.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: FISH, ICC/IF, IP, WB.

Showing Publications 1 - 10 of 22. Show All 22 Publications. Collapse Publications.

Publications using NB100-292	Applications	Species
Nicole Bettin, Emmanuelle Querido, Irene Gialdini, Glenda Paola Grupelli, Elena Goretti, Marta Cantarelli, Marta Andolfato, Eslam Soror, Alessandra Sontacchi, Katarina Jurikova, Pascal Chartrand, Emilio Cusanelli TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends Science Advances 2024-06-14 [PMID: 38865460]
Savoca V, Rivosecchi J, Gaiatto A et al. TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner Cell reports 2023-04-14 [PMID: 37060569] (ICC/IF, IP, WB, FISH, Human)	ICC/IF, IP, WB, FISH	Human
Swanson MJ, Lewis KN, Carpenter R et al. The human RAP1 and GFAP? proteins increase ?-secretase activity in a yeast model system G3 (Bethesda, Md.) 2023-03-17 [PMID: 36929840]
Avogaro L, Querido E, Dalachi M et al. Live-cell imaging reveals the dynamics and function of single-telomere TERRA molecules in cancer cells. RNA Biol 2018-04-16 [PMID: 29658398] (Human)		Human
Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014-11-03 [PMID: 25271372] (ICC/IF, Human)	ICC/IF	Human
Kocak H, Ballew BJ, Bisht K et al. Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. Genes Dev. 2014-10-01 [PMID: 25233904] (ICC/IF, Human)	ICC/IF	Human
Chen LY, Majerska J, Lingner J. Molecular basis of telomere syndrome caused by CTC1 mutations. Genes Dev. 2013-10-01 [PMID: 24115768] (ICC/IF, Human)	ICC/IF	Human
Kamranvar SA, Chen X, Masucci MG. Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus. Oncogene. 2013-05-27 [PMID: 23708666] (WB, Human)	WB	Human
Nandakumar J, Bell CF, Weidenfeld I et al. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012-12-13 [PMID: 23103865] (ICC/IF, Human)	ICC/IF	Human
Gu P, Min JN, Wang Y et al. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J 2012-04-01 [PMID: 22531781]
Canudas S, Houghtaling BR, Bhanot M et al. A role for heterochromatin protein 1{gamma} at human telomeres. Genes Dev. 2011-08-24 [PMID: 21865325]
Choi KH, Farrell AS, Lakamp AS et al. Characterization of the DNA binding specificity of Shelterin complexes. Nucleic Acids Res. 2011-11-01 [PMID: 21852327] Details: Tin2 (IMG-282) & POT1 (IMG-5343A). EMSA: HeLa cell line transfected with or without Flag-Tin2, Fig 4C.
Yang D, He Q, Kim H et al. TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase. J Biol Chem 2011-07-01 [PMID: 21536674]
Stohr BA, Blackburn EH. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res 2008-07-01 [PMID: 18593932]
Yang Q, Zhang R, Horikawa I et al. Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence. Cancer Res 2007-12-01 [PMID: 18089797]
Chen LY, Liu D, Songyang Z et al. Telomere maintenance through spatial control of telomeric proteins. Mol Cell Biol 2007-08-01 [PMID: 17562870]
Bae NS, Baumann P. A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell 2007-05-01 [PMID: 17499040]
Xu L, Blackburn EH. Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 2004-12-01 [PMID: 15583028]
Liu D, O'Connor MS, Qin J et al. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem 2004-12-01 [PMID: 15383534]
Liu D, Safari A, O'Connor MS et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol 2004-07-01 [PMID: 15181449]
O'Connor MS, Safari A, Liu D et al. The human Rap1 protein complex and modulation of telomere length. J Biol Chem 2004-07-01 [PMID: 15100233]
Kocak H. Functional Analysis of ACD Mutations in Dyskeratosis Congenita Thesis. 2014-01-01 (ICC/IF, Human)	ICC/IF	Human
Show All 22 Publications. Collapse Publications.

Array NB100-292

• TERF2IP Antibodies
• TERF2IP ELISA Kits
• TERF2IP Lysate
• TERF2IP Proteins