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POT1 Antibody [DyLight 350]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 350

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB500-176AF350
Alexa Fluor 405
NB500-176AF405
Alexa Fluor 488
NB500-176AF488
Alexa Fluor 532
NB500-176AF532
Alexa Fluor 594
NB500-176AF594
Alexa Fluor 647
NB500-176AF647
Alexa Fluor 700
NB500-176AF700
Alexa Fluor 750
NB500-176AF750
Allophycocyanin
NB500-176APC
Biotin
NB500-176B
CoraFluor 1
NB500-176CL1
DyLight 405
NB500-176V
DyLight 488
NB500-176G
DyLight 550
NB500-176R
DyLight 594
NB500-176DL594
DyLight 650
NB500-176C
DyLight 680
NB500-176FR
DyLight 755
NB500-176IR
HRP
NB500-176H
Janelia Fluor 525
NB500-176JF525
Janelia Fluor 549
NB500-176JF549
Janelia Fluor 585
NB500-176JF585
Janelia Fluor 635
NB500-176JF635
Janelia Fluor 646
NB500-176JF646
Janelia Fluor 669
NB500-176JF669
PE
NB500-176PE
PerCP
NB500-176PCP
Unconjugated
NB500-176
mFluor Violet 450 SE
NB500-176MFV450
mFluor Violet 500 SE
NB500-176MFV500
mFluor Violet 610 SE
NB500-176MFV610
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POT1 Antibody [DyLight 350] Summary

Immunogen
A synthetic peptide made to an internal portion of the human POT1 protein sequence (between residues 200-300). [UniProt# Q9NUX5]
Localization
Nuclear
Predicted Species
Primate (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
POT1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: monkey (95%), rat (82%), and mouse (72%).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for POT1 Antibody [DyLight 350]

  • DKFZp586D211
  • HPOT1
  • POT1 protection of telomeres 1 homolog
  • POT1
  • POT1-like telomere end-binding protein
  • protection of telomeres 1 homolog (S. pombe)
  • protection of telomeres protein 1

Background

POT1 (protection of telomeres 1), a telomere regulator, is a single-stranded telomeric DNA-binding protein that controls telomerase-mediated telomere elongation. Telomere maintenance is required for protection against changes in telomere length, which has been implicated in ageing and certain cancers. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Excessive transcriptional expression of POT1 has been associated with stomach cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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POT1 Antibody
[DyLight 350]
NB500-176UV
POT1 Antibody [DyLight 350]
Species: Hu, Pm
Applications: WB

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

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Telomeres are a region of repeat nucleotide sequences located at the end of chromosomes to protect our DNA from becoming damaged via end-to-end fusion.  TERF2, or telomeric-repeat binding factor 2, is important for telomere integrity and aids in th...  Read full blog post.
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Bioinformatics

Gene Symbol POT1