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POLG2 Antibody

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Immunohistochemistry-Paraffin: POLG2 Antibody [NBP1-83227] - Staining of human heart muscle shows cytoplasmic positivity.
Immunohistochemistry-Paraffin: POLG2 Antibody [NBP1-83227] - Staining of human heart muscle shows cytoplasmic positivity.
Immunohistochemistry-Paraffin: POLG2 Antibody [NBP1-83227] - Staining of human duodenum shows cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: POLG2 Antibody [NBP1-83227] - Staining of human kidney shows moderate granular cytoplasmic positivity in cells in tubules.
Immunohistochemistry-Paraffin: POLG2 Antibody [NBP1-83227] - Staining of human testis shows positivity in Leydig cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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POLG2 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: LDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTTMKE
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
POLG2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
POLG2 Protein (NBP1-83227PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (89%), Mouse (86%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for POLG2 Antibody

  • DNA polymerase gamma accessory 55 kDa subunit
  • DNA polymerase subunit gamma-2, mitochondrial
  • EC 2.7.7.7
  • HP55
  • Mitochondrial DNA polymerase accessory subunit
  • mitochondrial DNA polymerase subunit gamma-2
  • mitochondrial DNA polymerase, accessory subunit
  • MtPolB
  • MTPOLBPOLG-BETA
  • p55
  • PEOA4
  • POLB
  • POLGB
  • PolG-beta
  • polymerase (DNA directed), gamma 2, accessory subunit

Background

The accuracy of mitochondrial DNA (mtDNA) replication depends on the coordinated action of many nuclear-encoded proteins and on the correct balance of nucleotides within the mitochondrial matrix. mtDNA is replicated by DNA polymerase gamma, which is composed of a 140-kD catalytic subunit (POLG1; MIM 174763) and a 55-kD accessory subunit (POLG2).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol POLG2