Perilipin-3/TIP47 Antibody

TIP47 (tail-interacting protein 47) is a member of PAT family of proteins (perilipin, ADRP, S3-12 and OXPAT) which plays a key role in the packaging/storage of neutral lipids and is required for mannose 6-phosphate receptors (M6PR) transport from endosomes to trans-Golgi network (TGN). TIP47 localizes in cytoplasm, endosome membrane as peripheral membrane protein towards cytoplasmic side, core of lipid bodies/ lipid droplet, in lipid sails and in the envelope, and it interacts with M6PR, IGF2R etc. via the cytoplasmic domain. As a cargo protein, TIP47 facilitates the delivery of M6PR from endosomes to TGN where it binds to cytoplasmic domains of cation-independent/-dependent M6PR and translocates to late endosomes by binding to Rab9 GTPase. Like other PAT family members, TIP47 associates with lipid droplets and influence insulin signaling as evidenced by combined knockout of ADRP /TIP47 leading to decreased insulin sensitivity. During HIV-1 infection, TIP47 acts as a cellular cofactor playing a part in Env incorporation, allowing the encounter and physical association between HIV-1 Gag and Env proteins during viral assembly process. TIP47 is identical to pregnancy-related placental tissue protein 17b (PP17b) and is overexpressed in cervical carcinoma patients wherein it is considered a serum tumor marker.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using NB110-40764	Applications	Species
Ibayashi M, Tatsumi T, Tsukamoto S. Perilipin2 depletion causes lipid droplet enlargement in the ovarian corpus luteum in mice The Journal of Reproduction and Development 2024-07-15 [PMID: 39010158]
Junichiro MITSUI, Megumi IBAYASHI, Ryutaro AIZAWA, Tomonori ISHIKAWA, Naoyuki MIYASAKA, Satoshi TSUKAMOTO Lipid droplets synthesized during luteinization are degraded after pregnancy The Journal of Reproduction and Development 2024-02-04 [PMID: 38311402]
Menon D, Bhapkar A, Manchandia B et al. ARL8B mediates lipid droplet contact and delivery to lysosomes for lipid remobilization Cell reports 2023-10-31 [PMID: 37777960] (ICC/IF, Human)	ICC/IF	Human
Bajpeyi S, Apaflo JN, Rosas V et al. Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression European journal of applied physiology 2023-06-27 [PMID: 37368137]
Antony R, Aby K, Gao H et al. UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle Frontiers in physiology 2022-04-07 [PMID: 35464088] (WB, Mouse)	WB	Mouse
Whytock KL, Parry SA, Turner MC et al. A high-fat high-calorie diet induces fibre-specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle J. Physiol. (Lond.) 2020-01-20 [PMID: 31958145] (ICC/IF, Human)	ICC/IF	Human
Helsley RN, Varadharajan V, Brown AL et al. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease Elife 2019-10-17 [PMID: 31621579] (Mouse)		Mouse
Keenan SN, Meex RC, Lo JCY et al. Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice. Diabetes 2019-01-07 [PMID: 30617219] (WB, Mouse)	WB	Mouse
Covington JD. THE EFFECTS OF AEROBIC EXERCISE AND LIPOLYTIC STIMULATION ON SKELETAL MUSCLE AND ADIPOSE EXPRESSION OF PERILIPIN 3 (PLIN3) IN INDIVIDUALS WITH TYPE 2 DIABETES AND WOMEN WITH POLYCYSTIC OVARY SYNDROME. Thesis. 2017-01-01 (Human)		Human
Adam M, Heikela H, Sobolewski C, Portius D. Hydroxysteroid (17b) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice. FASEB J. 2018-01-31 [PMID: 29401633] (WB, Mouse)	WB	Mouse
Xu M, Zeng Y, Chi D et al. The dynamic pattern of PLIN3 in pig oocytes and cumulus cells during in vitro maturation Zygote 2018-02-01 [PMID: 29233207] (Porcine)		Porcine
Covington JD, Johannsen DL, Coen PM et al. Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding Obesity (Silver Spring). 2017-12-01 [PMID: 29071793]
Kuo A, Lee MY, Sessa WC. Lipid Droplet Biogenesis and Function in the Endothelium. Circ. Res. 2017-01-24 [PMID: 28119423]
Covington JD, Noland RC, Hebert RC et al. Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary and Type 2 Diabetic Males. J. Clin. Endocrinol. Metab. 2015-07-14 [PMID: 26171795]
Covington Jd, Bajpeyi S, Moro C et al. Effects of exercise training in women with polycystic ovary syndrome on adipose expression of perilipin 3. Eur. J. Endocrinol. 2014-10-23 [PMID: 25342854] (WB, Human)	WB	Human
Covington JD, Galgani JE, Moro C et al. Skeletal Muscle Perilipin 3 and Coatomer Proteins Are Increased following Exercise and Are Associated with Fat Oxidation. PLoS ONE 2014-03-17 [PMID: 24632837] (WB, Human)	WB	Human
Wolins NE, Quaynor BK, Skinner JR et al. S3-12, Adipophilin, and TIP47 package lipid in adipocytes. J Biol Chem 280(19):19146-55. 2005-05-13 [PMID: 15731108] (WB, ICC/IF, Mouse, Human)	WB, ICC/IF	Mouse, Human
Show All 17 Publications. Collapse Publications.

Array NB110-40764

• Perilipin-3/TIP47 Antibodies
• Perilipin-3/TIP47 ELISA Kits
• Perilipin-3/TIP47 Lysate
• Perilipin-3/TIP47 Proteins