OXPAT Antibody - BSA Free

OXPAT (PLIN5/Perilipin 5) is a novel PAT-1 (Perilipin, ADRP and TIP47) that binds to lipid droplets (LDs) and protects them from lipolytic degradation. The tissue distribution of PAT-1 proteins differs considerably, however, all of them are involved in accumulation and metabolism of lipids in LDs. OXPAT covers LDs in the cytosol and its expression is highest in tissues with a high fat-oxidative capacity, such as heart, oxidative (type I) skeletal muscles and brown adipose tissue wherein the OXPAT contents parallel the LD content. OXPAT overexpression in OP-9 and COS-7 cells increased cellular triglyceride storage in parallel with increases in fatty acid oxidation and induction of gene expression of mitochondrial enzymes involved in oxidative metabolism. OXPAT has the potential of modulating the interaction of the major triacylglycerol lipase ATGL with LD as well as with its co-factor CGI-58 in a well control manner to regulate LD lipolysis. OXPAT expression is up-regulated by PPARalpha, and this regulation appears to be part of an expression program that shifts the metabolism of cells from fatty acid storage to oxidation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 6 applications: FLOW, ICC/IF, IHC-Fr, IP, Immunohistochemistry, WB.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NB110-60509	Applications	Species
Gan X, Zhao J, Chen Y et al. Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1alpha following vascular injury Bioengineered 2022-04-01 [PMID: 35470759] (WB, IP, Mouse)	WB, IP	Mouse
Fillmore N, Hou V, Sun J et al. Cardiac specific knock-down of peroxisome proliferator activated receptor alpha prevents fasting-induced cardiac lipid accumulation and reduces perilipin 2 PloS one 2022-03-08 [PMID: 35259201] (WB, Mouse)	WB	Mouse
Miao H, Li B, Wang Z et al. Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation Research 2022-01-01 (WB, Mouse) Details: Dilution used in WB 1:500	WB	Mouse
Zhao Y, Albrecht E, Li Z et al. Distinct Roles of Perilipins in the Intramuscular Deposition of Lipids in Glutamine-Supplemented, Low-, and Normal-Birth-Weight Piglets Frontiers in Veterinary Science 2021-06-21 [PMID: 34235195] (Immunohistochemistry)	Immunohistochemistry
Zhong W, Fan B, Cong H et al. Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPAR alpha pathway in HepG2 cells Appl Physiol Nutr Metab 2019-08-01 [PMID: 31274012]
Larsen Steen, Vigelso Andreas, Dandanell Sune et al. Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study. J Diabetes Res. 2018-09-12 [PMID: 30276217] (WB, Human)	WB	Human
Kristensen MD, Petersen SM, Moller KE et al. Obesity leads to impairments in the morphology and organization of human skeletal muscle lipid droplets and mitochondrial networks, which are resolved with gastric bypass surgery-induced improvements in insulin sensitivity Acta Physiol (Oxf) 2018-05-23 [PMID: 29791782] (Human)		Human
Lambertz J, Berger T, Mak TW et al. Lipocalin-2 in Fructose-Induced Fatty Liver Disease. Front Physiol 2017-11-28 [PMID: 29234288] (Mouse)		Mouse
Zappaterra M, Mazzoni M, Zambonelli P, Davoli R. Investigation of the Perilipin 5 gene expression and association study of its sequence polymorphism with meat and carcass quality traits in different pig breeds animal. 2017-11-02 [PMID: 29094660] (Porcine)		Porcine
Vigelso A, Gram M, Wiuff C et al. Effects of immobilization and aerobic training on proteins related to intramuscular substrate storage and metabolism in young and older men. Eur. J. Appl. Physiol. 2015-12-01 [PMID: 26626913] (WB, Human)	WB	Human
Revuelta-Lopez E, Cal R, Julve J et al. Hypoxia worsens the impact of intracellular triglyceride accumulation promoted by electronegative low-density lipoprotein in cardiomyocytes by impairing perilipin 5 upregulation. Int J Biochem Cell Biol 2015-08-01 [PMID: 26096040]
Fahrenbach JP, Stoller D, Kim G et al. Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J. 2014-03-19 [PMID: 24648545] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Pantha R, Lee J, Bae J et al. LRH-1 Ameliorates Hepatic Triglyceride Accumulation via Regulation of Perilipin 5 in the Liver Preprints 2021-02-12 (ICC/IF, Mouse)	ICC/IF	Mouse
Vigelso, A, Prats, C Et al. Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men. Physiol Res 2016-06-20 [PMID: 26447519] (FLOW, Human) Details: Citation using the PE/Cy7 format of this antibody.	FLOW	Human
Dahl N Development of skeletal muscle and adipose tissues in neonatal dairy calves upon a maternal supplementation with essential fatty acids and conjugated linoleic acids Thesis 2022-01-01
Antony R, Aby K, Gao H et al. UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle Frontiers in physiology 2022-04-07 [PMID: 35464088] (WB, Mouse)	WB	Mouse
Show All 16 Publications. Collapse Publications.

Array NB110-60509

• OXPAT Antibodies
• OXPAT ELISA Kits
• OXPAT Proteins