Perilipin Antibody

Perilipin is a member of the perilipin or PAT family which includes perilipin or perilipin 1 (PLIN1), ADRP/perilipin 2, TIP47/perilipin 3, S3-12/perilipin 4, and LSDP5/perilipin 5 (also called OXPAT). PLIN1 is localized on lipid droplet surfaces in adipocytes and steroidogenic cells wherein it plays a key role in basal/stimulated lipid storage as well as breakdown. Under basal conditions, perilipin protects the lipid core from lipases (e.g. hormone-sensitive lipase and adipocyte TAG lipase) and co-activator CGI-58 by sequestering the enzymes from the lipid droplet surfaces. However, upon beta-adrenergic stimulation, PKA phosphorylates PLIN1 and causes the release of CGI-58 so it can bind and stimulate ATGL and also allows/recruits HSL to translocate to the lipid droplet surface. PLIN1 knockout increases basal lipolysis and decreases LD size in adipocytes and causes resistance to diet induced obesity in mice. In humans, lower PLIN1 expression is associated with higher rates of lipolysis and mutation in PLIN1 or its expression in obese human adipose tissue, correlates positively with insulin sensitivity, and have been established as the cause of familial partial lipodystrophy type 4 (FPLD4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: ICC/IF, IF/IHC, IHC-P, Immunohistochemistry, WB, Western Blot.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using NB110-40760	Applications	Species
Pedrosa M, Labandeira C, Lago-Baameiro N et al. Extracellular Vesicles and Their Renin-Angiotensin Cargo as a Link between Metabolic Syndrome and Parkinson’s Disease Antioxidants 2023-11-26 [PMID: 38136165]
Wei F, Tuong ZK, Omer M et al. A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss Bone research 2023-06-29 [PMID: 37385982] (IHC-P, Rat)	IHC-P	Rat
Wang R, Nissen NN, Zhang Y Et al. Circulating Fatty Objects and Their Preferential Presence in Pancreatic Cancer Patient Blood Samples Front Physiol 2022-03-03 [PMID: 35237181] (Human) Details: Citation using the Biotin version of this antibody.		Human
Otani N, Tomita K, Kuroda K et al. Effects of Temporary and Permanent Muscle Denervation on Fat Graft Retention in the Latissimus Dorsi Muscle: An Experimental Study in Rats Aesthetic plastic surgery 2022-02-28 [PMID: 35226118]
Mahesh M, Pandey H, Raja Gopal Reddy M et al. Carrot Juice Consumption Reduces High Fructose-Induced Adiposity in Rats and Body Weight and BMI in Type 2 Diabetic Subjects Nutr Metab Insights 2021-08-05 [PMID: 34349520]
Zhao Y, Albrecht E, Li Z et al. Distinct Roles of Perilipins in the Intramuscular Deposition of Lipids in Glutamine-Supplemented, Low-, and Normal-Birth-Weight Piglets Frontiers in Veterinary Science 2021-06-21 [PMID: 34235195] (Immunohistochemistry)	Immunohistochemistry
Andrei SR. Characterization of TRP Ion Channels in Cardiac Muscle. Thesis. 2017-01-01 (WB, Mouse)	WB	Mouse
Li C, Xu J, Yu Q et al. Mutation of the novel acetylation site at K414R of BECN1 is involved in adipocyte differentiation and lipolysis Journal of Cellular and Molecular Medicine 2021-07-01 [PMID: 34085745] (Western Blot)	Western Blot
Kasza I, K�hn JP, V�lzke H et al. Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human The Journal of Physiology 2022-02-01 [PMID: 33724479] (Immunohistochemistry)	Immunohistochemistry
Brigger D, Riether C, van Brummelen R et al. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age Nat Metab 2020-07-06 [PMID: 32694825] (IF/IHC, Mouse)	IF/IHC	Mouse
Kasza I, Adler D, Nelson D et al. Evaporative Cooling Provides a Major Metabolic Energy Sink Molecular Metabolism 2019-07-01 [PMID: 31302039] (ICC/IF, Mouse)	ICC/IF	Mouse
Listenberger L, Townsend E, Rickertsen C et al. Decreasing Phosphatidylcholine on the Surface of the Lipid Droplet Correlates with Altered Protein Binding and Steatosis. Cells. 2018-11-24 [PMID: 30477200] (WB, Mouse)	WB	Mouse
HA Himburg, CM Termini, L Schlussel, J Kan, M Li, L Zhao, T Fang, JP Sasine, VY Chang, JP Chute Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration Cell Stem Cell, 2018-08-09;0(0):. 2018-08-09 [PMID: 30100167]
Finlin BS, Memetimin H, Confides AL et al. Human adipose beiging in response to cold and mirabegron. JCI Insight 2018-08-09 [PMID: 30089732] (IF/IHC, Human) Details: This citation used the Alexa Fluor 488 version of this antibody.	IF/IHC	Human
Maisano M, Cappello T, Oliva S et al. PCB and OCP accumulation and evidence of hepatic alteration in the Atlantic bluefin tuna, T. thynnus, from the Mediterranean Sea. Mar Environ Res 2016-10-01 [PMID: 27012897]
Manzano-Roman, R et al. Expression of perilipin in human promyelocytic cells in response to Anaplasma phagocytophilum infection results in modified lipid metabolism. J Med Microbiol 57(Pt 2):159-63. 2008-02-01 [PMID: 18201980] (ICC/IF, Human)	ICC/IF	Human
Kadereit,B et al. Evolutionarily conserved gene family important for fat storage. Proc Natl Acad Sci U S A;105(1):94-9. 2008-01-08 [PMID: 18160536] (WB, Mouse)	WB	Mouse
Show All 17 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IMC	Human	02/22/2021	View Summary Application Imaging Mass Cytometry Sample Tested bone marrow Species Human Lot D-7 Comments Comments Conjugated with 151Eu and used 1:50 on human bone marrow FFPE. Perilipin - red DNA- white ***Bio-Techne Response: This review was submitted through the legacy Novus Innovators Program, reflecting a new species or application tested on a primary antibody.***

Array NB110-40760

• Perilipin Antibodies
• Perilipin ELISA Kits
• Perilipin Lysates
• Perilipin Proteins