NGFR/TNFRSF16/p75NTR Antibody

p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP1-85769	Applications	Species
Wilcox M B, Laranjeira S G et al. Characterising cellular and molecular features of human peripheral nerve degeneration. Acta Neuropathol Commun 2020-04-17 [PMID: 32303273] (IF/IHC, Human)	IF/IHC	Human
Karbalaie K, Tanhaei S, Rabiei F et al. Stem Cells from Human Exfoliated Deciduous Tooth Exhibit Stromal-Derived Inducing Activity and Lead to Generation of Neural Crest Cells from Human Embryonic Stem Cells. Cell J 2015-01-01 [PMID: 25870833] (ICC/IF, Human)	ICC/IF	Human
Krahl D, Sellheyer K. p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology. Br J Dermatol 2010-07-01 [PMID: 20184585]

Array NBP1-85769

• NGFR/TNFRSF16/p75NTR Antibodies
• NGFR/TNFRSF16/p75NTR Lysate
• NGFR/TNFRSF16/p75NTR Proteins
• NGFR/TNFRSF16/p75NTR Proteins and Enzymes
• NGFR/TNFRSF16/p75NTR ELISAs