Mouse CD25/IL-2R alpha DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD25/IL-2 receptor alpha is a transmembrane protein that associates with IL-2 R beta/CD122 and the Common gamma Chain/CD132 on activated T cells and regulatory T cells (Treg). The Common gamma chain is a shared subunit in the receptors for IL-4, -7, -9, -15, and -21. IL-2 R alpha is required for mediating IL-2 induced effects including T cell proliferation, activation induced cell death (AICD) of autoreactive naive T cells, and the development of CD4+CD25+ Treg which contribute to peripheral T cell homeostasis. A soluble form of IL-2 R alpha can be generated by proteolytic cleavage of the cell surface receptor.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using DY2438	Applications	Species
Mann, J;Runge, S;Schell, C;Gräwe, K;Thoulass, G;Lao, J;Ammann, S;Grün, S;König, C;Berger, SA;Hild, B;Aichele, P;Rosshart, SP;Ehl, S; The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin-Deficient Mice European journal of immunology 2024-11-16 [PMID: 39548906] (Transgenic Mouse)		Transgenic Mouse
Yap, J;Yuan, J;Ng, WH;Chen, GB;Sim, YRM;Goh, KC;Teo, J;Lim, TYH;Goay, SM;Teo, JHJ;Lao, Z;Lam, P;Sabapathy, K;Hu, J; BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes Molecular cancer 2023-08-05 [PMID: 37543582] (Mouse)		Mouse
Diamond, T;Lau, M;Morrissette, J;Chu, N;Behrens, EM; CXCL9 inhibition does not ameliorate disease in murine models of both primary and secondary hemophagocytic lymphohistiocytosis Scientific reports 2023-07-29 [PMID: 37516815] (Mouse)		Mouse
K Wei beta ert, S Ammann, T Kögl, V Dettmer-Mo, C Schell, T Cathomen, S Ehl, P Aichele Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH) Embo Molecular Medicine, 2022-10-24;0(0):e16085. 2022-10-24 [PMID: 36278424] (Mouse)		Mouse
T Diamond, TN Burn, MA Nishiguchi, D Minichino, J Chase, N Chu, PA Kreiger, EM Behrens Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-gamma in a predominantly hepatic-intrinsic manner PLoS ONE, 2022-06-07;17(6):e0269553. 2022-06-07 [PMID: 35671274] (Mouse)		Mouse
S Kirschke, I Ogunsulire, B Selvakumar, N Schumacher, T Sezin, S Rose-John, A Scheffold, C Garbers, J Lokau The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sIL-2Ralpha/sCD25) in vivo The Journal of Biological Chemistry, 2022-04-07;0(0):101910. 2022-04-07 [PMID: 35398356] (Mouse)		Mouse
R Gather, P Aichele, N Goos, J Rohr, H Pircher, T Kögl, R Zeiser, H Hengel, A Schmitt-Gr, C Weaver, S Ehl Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis Eur. J. Immunol., 2020-06-02;0(0):. 2020-06-02 [PMID: 32419134] (Mouse)		Mouse
SJ Tavernier, V Athanasopo, P Verloo, G Behrens, J Staal, DJ Bogaert, L Naesens, M De Bruyne, S Van Gassen, E Parthoens, J Ellyard, J Cappello, LX Morris, H Van Gorp, G Van Isterd, Y Saeys, M Lamkanfi, P Schelstrae, J Dehoorne, V Bordon, R Van Coster, BN Lambrecht, B Menten, R Beyaert, CG Vinuesa, V Heissmeyer, M Dullaers, F Haerynck A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation Nat Commun, 2019-10-21;10(1):4779. 2019-10-21 [PMID: 31636267] (Mouse)		Mouse
EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells Nature, 2016-05-05;533(7601):110-4. 2016-05-05 [PMID: 27147029] (Mouse)		Mouse
Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Langler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Graeff A, Aichele P, Zur Stadt U, Schwarz K, Ehl S Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood, 2011-08-30;118(17):4620-9. 2011-08-30 [PMID: 21878672] (Mouse)		Mouse
Secor ER, Singh A, Guernsey LA Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro. Int. Immunopharmacol., 2009-01-20;9(3):340-6. 2009-01-20 [PMID: 19162239] (Mouse)		Mouse
Show All 11 Publications. Collapse Publications.

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