CD69 Antibody (15B5G2) - BSA Free

CD69 is a transmembrane C-type lectin broadly expressed on the cell surface of activated leukocytes, including T and B lymphocytes, neutrophils, natural killer cells, and eosinophils, and is constitutively expressed on the surface of monocytes and platelets (Vance BA et al., 2005 15893733). The abundance of CD69 rapidly increases after cell activation in all bone marrow-derived cells except erythrocytes (Martin P et al., 2011 21427408). It is an early lymphocyte activation antigen and a universal leukocyte triggering molecule expressed at sites of active immune response (Kavan D et al., 2010 20369839). CD69 plays a key role in early inflammation and modulation of adaptive immune responses through the production of a variety of cytokines and lymphocyte migration. Expression of CD69 has been observed in human diseases. Moreover, anti-CD69 monoclonal antibodies have therapeutic effect in the treatment process of different animal models of cancer and autoimmune disorders (Vazquez BN et al., 2012 22456278). Surface-expressed CD69 is an activation marker for basophils and is strongly induced by IL-3. Upregulated CD69 expression on locally accumulated basophils in bronchial asthma attributed at least in part to a combination of local cytokines, especially IL-3, plus exposure to low levels of IgE-crosslinking allergens (Suzukawa M et al., 2007 17541278).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publication 1 - 1 of 1.

Publication using NBP2-25236	Applications	Species
Willemsen M, Tio D, Krebbers G et al. Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma The American Journal of dermatopathology 2022-03-21 [PMID: 35311751] (IF/IHC, Human)	IF/IHC	Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-P	Human	11/06/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested Human lymph node Species Human Lot 032045315G2-01

Array NBP2-25236

• CD69 Antibodies
• CD69 Antibody Pair
• CD69 ELISA Kits
• CD69 Lysate
• CD69 Protein
• CD69 Proteins and Enzymes