Mitofusin 1 Antibody - BSA Free

Manufactured by Genomic Antibody Technology™. GAT FAQs

Mitochondria are dynamic organelles that continuously divide and fuse, and their dynamics/distribution is critical for their role in bioenergetics and cell survival. Mitochondrial fusion process is mediated by mitofusin 1 (MFN1) and mitofusin 2 (MFN2) proteins in the outer membrane as well as OPA1 in the inner mitochondrial membrane. MFN1 is an essential transmembrane GTPase critical to mitochondrial fusion; acts independently of the cytoskeleton, and its overexpression induces formation of mitochondrial networks. MFN1 forms homo-/-heteromultimers (with MFN2), and the multimerization has been proposed to be essential for mitochondrion fusion. MFN1 interacts with VAT1 and is ubiquitinated by MARCH5. A mutation in the GTPase domain disrupts the mitochondrial fusion activity of MFN1/MFN2 and loss of MFN1/2 leads to mitochondrial dysfunction mediated embryonic lethality in mice. MFN proteins have been reported to regulate mitochondrial membrane potential, while silencing of MFN1/2 resulte in mitochondrial fragmentation and increased apoptotic sensitivity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Sheep.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 10 of 10.

Publications using NBP1-51841	Applications	Species
Ramasubramanian B, Griffith C, Hanson M et al. Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO Cells 2022-02-21 [PMID: 35203393] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Chidipi B, Angulo MB, Shah SI et al. The dynamin-related protein 1 is decreased and the mitochondrial network is altered in Friedreich's ataxia cardiomyopathy The international journal of biochemistry & cell biology 2021-12-16 [PMID: 34923139] (WB, Human)	WB	Human
Jingwen Zhang, Zhibin He, Julia Fedorova, Cole Logan, Lauryn Bates, Kayla Davitt, Van Le, Jiayuan Murphy, Melissa Li, Mingyi Wang, Edward G. Lakatta, Di Ren, Ji Li Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility Aging Cell 2021-07-03 [PMID: 34216536]
Singh Bhatti J, Tamarai K, Kandimalla R et al. Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice Mitochondrion 2021-02-24 [PMID: 33639273] (WB, Mouse)	WB	Mouse
Panes, J D, Godoy, P A Et al. Changes in PGC-1 alpha /SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model. Front Pharmacol 2020-06-12 [PMID: 32523530] (IF/IHC, Sheep)	IF/IHC	Sheep
Lin H, Magrane J, Rattelle A et al. Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia Dis Model Mech. 2017-11-01 [PMID: 29125827] (WB, Mouse)	WB	Mouse
Chung E, Joiner HE, Skelton T et al. Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts. Physiol Rep. 2017-03-01 [PMID: 28292876] (WB, Mouse)	WB	Mouse
Wang X, Yang H, Yanagisawa D et al. Mitochondrial ferritin affects mitochondria by stabilizing HIF-1alpha in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration. Neurobiol Aging 2016-11-01 [PMID: 27599360] (WB)	WB
Reddy PH, Manczak M, Yin X et al. Protective effects of a natural product, curcumin, against amyloid beta induced mitochondrial and synaptic toxicities in Alzheimer's disease. J. Investig. Med. 2016-12-01 [PMID: 27521081] (WB, Human)	WB	Human
Miller MW, Knaub LA, Olivera-Fragoso LF et al. Nitric oxide regulates vascular adaptive mitochondrial dynamics. Am J Physiol Heart Circ Physiol. 2013-06-15 [PMID: 23585138] (WB, Rat)	WB	Rat

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Vasundhra Bahl	ICC	Mouse	03/28/2014	View Summary Application Immunocytochemistry Sample Tested Paraformeldehyde Fixed Cells Species Mouse

Array NBP1-51841

• Mitofusin 1 Antibodies
• Mitofusin 1 Lysate
• Mitofusin 1 Proteins