MCM2 [p Ser108] Antibody

MCM2 (Mini chromosome maintenance protein 2) is involved in regulating DNA replication. MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. It is similar to members of the family of early S-phase proteins. Mincheva et al. (1994) mapped the gene to 3q21. From its localization, CDCL1 became a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NB100-639	Applications	Species
Izawa N, Wu W, Sato K et al. HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression. Cancer Res 2011-09-01 [PMID: 21775519]
Kemp MG, Akan Z, Yilmaz S et al. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem 2010-05-01 [PMID: 20233725]
Krasinska L, Fisher D. Replication initiation complex formation in the absence of nuclear function in Xenopus. Nucleic Acids Res 2009-04-01 [PMID: 19237397]
Trenz K, Errico A, Costanzo V et al. Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J 2008-03-01 [PMID: 18309293]
Liu E, Lee AY, Chiba T et al. The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. J Cell Biol 2007-11-01 [PMID: 18025301]
Cortez D, Glick G, Elledge SJ et al. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A 2004-07-01 [PMID: 15210935]

Array NB100-639

• MCM2 Antibodies
• MCM2 ELISA Kits
• MCM2 Lysate
• MCM2 Proteins