Geminin Antibody (1A8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Geminin is a multifunctional nuclear protein invloved in embyro development/differentiation, cell cycle regulation and DNA replciation. Originally defined as an inhibitor of DNA replication and substrate of the anaphase promoting complex, Geminin has also been shown to expand the neural plate in the developing embryos.

Geminin prevents DNA replication by blocking the MCM complex incorporation into prereplication complex (pre-RC). It is absent during the G1 phase and accumulates during the S, G2, and M phases of mitosis. Geminin is then degraded during the metaphase-anaphase trasitio,n allowing replication to occur during subsequent cycles.

Geminin antibodies are useful tools for a variety of research including developmental embryology, stem cell differentiation, neuroscience, and DNA replication studies.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 3 of 3.

Publications using H00051053-M01	Applications	Species
Averbeck NB, Barent C, Jakob B et al. The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells Cells 2022-08-17 [PMID: 36010636] (ICC/IF, Human)	ICC/IF	Human
Nacson J, Krais JJ, Bernhardy AJ et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Rep 2018-09-25 [PMID: 30257212]
Wang Y, Bernhardy AJ, Cruz C et al. The BRCA1-delta11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin Cancer Res 2016-05-15 [PMID: 27197267]

Array H00051053-M01

• Geminin Antibodies
• Geminin ELISA Kit
• Geminin Lysate
• Geminin Proteins