MCM2 Antibody

MCM2 is encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-288	Applications	Species
Depreux FF, Puckelwartz MJ, Augustynowicz A et al. Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Hum. Mol. Genet. 2015-05-06 [PMID: 25948554]
Hubbi ME, Gilkes DM, Hu H et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1alpha to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014-07-28 [PMID: 25071185] (WB, Human)	WB	Human
Hubbi ME, Kshitiz, Gilkes DMet al. A nontranscriptional role for HIF-1alpha as a direct inhibitor of DNA replication. Sci Signal 2013-02-12 [PMID: 23405012]
Isaacs JT, D'Antonio JM, Chen S et al. Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer. Prostate 2012-10-01 [PMID: 22396319]
Hubbi ME, Luo W, Baek JH et al. MCM proteins are negative regulators of hypoxia-inducible factor 1 Mol Cell 2011-06-10 [PMID: 21658608] (WB, Human)	WB	Human
Gueranger Q, Kia A, Frith D et al. Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA. Nucleic Acids Res 2011-07-01 [PMID: 21398635]
Kadara H, Behrens C, Yuan P et al. A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis Clin Cancer Res 2011-03-15 [PMID: 21163870] (IF/IHC, Human)	IF/IHC	Human
Snyder M, Huang XY, Zhang JJ et al. The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription. J Biol Chem 2009-05-01 [PMID: 19318354]
Pacek M, Tutter AV, Kubota Y et al. Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell 2006-02-01 [PMID: 16483939]

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	08/10/2010	View Summary Application Western Blot Sample Tested 293T Western Cell lysate Species Human
	3 reviewed by: Verified Customer	WB	Human	01/26/2010	View Summary Application Western Blot Sample Tested HCT116 Cell Lysate, Sample Amount: 50 ug Species Human

Array NB100-288

• MCM2 Antibodies
• MCM2 ELISA Kits
• MCM2 Lysate
• MCM2 Proteins