Geminin Products

Description

Geminin is a multifunctional nuclear protein invloved in embyro development/differentiation, cell cycle regulation and DNA replciation. Originally defined as an inhibitor of DNA replication and substrate of the anaphase promoting complex, Geminin has also been shown to expand the neural plate in the developing embryos.

Geminin prevents DNA replication by blocking the MCM complex incorporation into prereplication complex (pre-RC). It is absent during the G1 phase and accumulates during the S, G2, and M phases of mitosis. Geminin is then degraded during the metaphase-anaphase trasitio,n allowing replication to occur during subsequent cycles.

Geminin antibodies are useful tools for a variety of research including developmental embryology, stem cell differentiation, neuroscience, and DNA replication studies.

Bioinformatics

Entrez	51053 Human
Uniprot	AAH05185 Human NM_015895 Human NP_056979 Human NP_056979.1 Human O75496 Human
Product By Gene ID	51053
Alternate Names	Gem geminin geminin, DNA replication inhibitor RP3-369A17.3

Research Areas for Geminin

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cell Cycle and Replication
Chromatin Research
Core ESC-Like Genes
DNA Repair
DNA replication, Transcription, Translation and Splicing
Nuclear Receptors, Coactivators and Corepressors
Stem Cell Markers