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Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) [DyLight 550]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, Func
Clone
4H8 WH2
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 550

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-80054AF350
Alexa Fluor 350
NBP2-80053AF350
Alexa Fluor 405
NBP2-80054AF405
Alexa Fluor 405
NBP2-80053AF405
Alexa Fluor 488
NBP2-80053AF488
Alexa Fluor 488
NBP2-80054AF488
Alexa Fluor 532
NBP2-80054AF532
Alexa Fluor 532
NBP2-80053AF532
Alexa Fluor 594
NBP2-80053AF594
Alexa Fluor 594
NBP2-80054AF594
Alexa Fluor 647
NBP2-80053AF647
Alexa Fluor 647
NBP2-80054AF647
Alexa Fluor 700
NBP2-80054AF700
Alexa Fluor 700
NBP2-80053AF700
Alexa Fluor 750
NBP2-80053AF750
Alexa Fluor 750
NBP2-80054AF750
Allophycocyanin
NBP2-80054APC
Allophycocyanin
NBP2-80053APC
Biotin
NBP2-80054B
Biotin
NBP2-80053B
DyLight 350
NBP2-80054UV
DyLight 350
NBP2-80053UV
DyLight 405
NBP2-80054V
DyLight 405
NBP2-80053V
DyLight 488
NBP2-80053G
DyLight 488
NBP2-80054G
DyLight 550
NBP2-80053R
DyLight 594
NBP2-80053DL594
DyLight 594
NBP2-80054DL594
DyLight 650
NBP2-80053C
DyLight 650
NBP2-80054C
DyLight 680
NBP2-80053FR
DyLight 680
NBP2-80054FR
DyLight 755
NBP2-80054IR
DyLight 755
NBP2-80053IR
FITC
NBP2-80053F
FITC
NBP2-80054F
HRP
NBP2-80053H
Janelia Fluor 549
NBP2-80054JF549
Janelia Fluor 549
NBP2-80053JF549
Janelia Fluor 646
NBP2-80054JF646
Janelia Fluor 646
NBP2-80053JF646
PE
NBP2-80053PE
PE
NBP2-80054PE
PerCP
NBP2-80054PCP
PerCP
NBP2-80053PCP
Unconjugated
NBP2-80053
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-80053
BSA Free
NBP2-80053
Azide and BSA Free
NBP2-80054
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Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) [DyLight 550] Summary

Immunogen
Recombinant mouse Lymphotoxin beta R/TNFRSF3 (cysteine-rich region/aa 31-221).
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
LTBR
Purity
>95%, by SDS-PAGE
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Functional Assay
Application Notes
The monoclonal antibody to mouse LT-beta-R is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappa-B family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappa-B2 pathway. For use as an agonist the MAb to LT-beta-R is added to cell cultures at 2ug/ml. For in vivo use, mice are injected intraperitoneally with 50ug of agonistic MAb to LT-beta-R in sterile phosphate saline buffer. Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
>95%, by SDS-PAGE

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) [DyLight 550]

  • CD18
  • D12S370
  • ltbetar
  • LT-BETA-R
  • LTBR
  • lymphotoxin B receptor
  • Lymphotoxin beta R
  • lymphotoxin beta receptor (TNFR superfamily, member 3)
  • Lymphotoxin-beta receptor
  • LymphotoxinbR
  • TNF RIII
  • TNF Rrp
  • TNFCRTNF-RIII
  • TNFR superfamily, member 3
  • TNFR2-RP
  • TNFR3
  • TNF-R-III
  • TNFR-RP
  • TNFRSF3
  • TNFRSF3TNFR-III
  • Tumor necrosis factor C receptor
  • Tumor necrosis factor receptor 2-related protein
  • tumor necrosis factor receptor superfamily member 3
  • tumor necrosis factor receptor superfamily, member 3
  • Tumor necrosis factor receptor type III

Background

LT-beta-R, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-beta-R is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LT-beta-R is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-beta-R is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-beta-R interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-beta-R has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LTBR