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Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) [DyLight 594]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, Func
Clone
4H8 WH2
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 594

Order Details

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Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) [DyLight 594] Summary

Immunogen
Recombinant mouse Lymphotoxin beta R/TNFRSF3 (cysteine-rich region/aa 31-221).
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
LTBR
Purity
>95%, by SDS-PAGE
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Functional Assay
Application Notes
The monoclonal antibody to mouse LT-beta-R is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappa-B family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappa-B2 pathway. For use as an agonist the MAb to LT-beta-R is added to cell cultures at 2ug/ml. For in vivo use, mice are injected intraperitoneally with 50ug of agonistic MAb to LT-beta-R in sterile phosphate saline buffer. Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
>95%, by SDS-PAGE

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) [DyLight 594]

  • CD18
  • D12S370
  • ltbetar
  • LT-BETA-R
  • LTBR
  • lymphotoxin B receptor
  • Lymphotoxin beta R
  • lymphotoxin beta receptor (TNFR superfamily, member 3)
  • Lymphotoxin-beta receptor
  • LymphotoxinbR
  • TNF RIII
  • TNF Rrp
  • TNFCRTNF-RIII
  • TNFR superfamily, member 3
  • TNFR2-RP
  • TNFR3
  • TNF-R-III
  • TNFR-RP
  • TNFRSF3
  • TNFRSF3TNFR-III
  • Tumor necrosis factor C receptor
  • Tumor necrosis factor receptor 2-related protein
  • tumor necrosis factor receptor superfamily member 3
  • tumor necrosis factor receptor superfamily, member 3
  • Tumor necrosis factor receptor type III

Background

LT-beta-R, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-beta-R is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LT-beta-R is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-beta-R is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-beta-R interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-beta-R has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LTBR