Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) - Azide and BSA Free Summary
Immunogen |
Recombinant mouse Lymphotoxin beta R/TNFRSF3 (cysteine-rich region/aa 31-221). |
Isotype |
IgG2a |
Clonality |
Monoclonal |
Host |
Rat |
Gene |
LTBR |
Purity |
Protein G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry
- Functional Assay
|
Application Notes |
The monoclonal antibody to mouse LT-beta-R is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappa-B family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappa-B2 pathway. For use as an agonist the MAb to LT-beta-R is added to cell cultures at 2ug/ml. For in vivo use, mice are injected intraperitoneally with 50ug of agonistic MAb to LT-beta-R in sterile phosphate saline buffer. |
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
PBS containing 10% glycerol |
Preservative |
No Preservative |
Concentration |
1 mg/ml |
Purity |
Protein G purified |
Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody (4H8 WH2) - Azide and BSA Free
Background
LT-beta-R, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT-beta-R is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LT-beta-R is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT-beta-R is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT-beta-R interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT-beta-R has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Lymphotoxin beta R/TNFRSF3 Antibody (NBP2-80054) (0)
Secondary Antibodies
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