LATS1 Antibody

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NB200-197	Applications	Species
Huang JM, Nagatomo I, Suzuki E et al. YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14. Oncogene 2012-06-01 [PMID: 22689061]
Mao Y, Mulvaney J, Zakaria S et al. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development 2011-03-01 [PMID: 21303848]
Salah Z, Melino G, Aqeilan RI et al. Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity. Cancer Res 2011-03-01 [PMID: 21212414]
Oh S, Lee D, Kim T et al. Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol 2009-12-01 [PMID: 19786569]
Zhang J, Smolen GA, Haber DA et al. Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res 2008-04-01 [PMID: 18413746]
Lee JH, Kim TS, Yang TH et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J 2008-04-01 [PMID: 18369314]

Array NB200-197

• LATS1 Antibodies
• LATS1 Proteins