Mouse myeloma cell line NS0-derived recombinant human Kallikrein 2 Ile25-Pro261 Accession # P20151
Specificity
Detects human Kallikrein 2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Kallikrein 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or B1 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KLK2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Kallikrein 2 Antibody (426723)
EC 3.4.21
EC 3.4.21.35
glandular kallikrein 2
Glandular kallikrein-1
hGK-1
hK2
Kallikrein 2
kallikrein 2, prostatic
kallikrein-2
kallikrein-related peptidase 2
Klk1c2
KLK2
KLK2A2
MGC12201
Tissue kallikrein-2
Ton
Background
Kallikrein 2 (KLK2) is a secreted serine protease that is highly expressed in the human prostate gland (1). It is also known as the prostate-specific glandular kallikrein. The enzyme is highly specific for cleavage after arginine residues. KLK2 is able to activate the urokinase-type plasminogen activator (2). KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen activator inhibitor 1 (3‑5). KLK2 is structurally related to KLK3, the prostate-specific antigen (PSA). Like PSA, KLK2 is considered to be a biomarker for prostate cancer (6).
Chapelaine, P. et al. (1988) FEBS Lett. 236:205.
Frenette, G. et al. (1997) Int. J. Cancer 71:897.
Deperthes, D. et al. (1995) Biochim. Biophys. Acta 1245:311.
Grauer, L.S. et al. (1998) J. Androl. 19:407.
MikolajczykS.D.et al. (1999) Cancer Res. 59:3927.
Sardana, G. et al. (2008) Clin. Chem. 54:1951.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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