IMP Dehydrogenase 2/IMPDH2 Antibody Summary
Immunogen |
Amino acids 221-248 from human IMPDH was used as the immunogen for this antibody. |
Predicted Species |
Orangutan (100%), Chimpanzee (100%), Zebrafish (100%), Fish (100%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
IMPDH2 |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 5ug/ml
- Immunohistochemistry-Paraffin
- Western Blot 2-4ug/ml~
|
Reactivity Notes
The amino acid sequence used as immunogen for this antibody is 100% homologous in White-cheeked Gibbon.
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
0.2 ml PBS and 0.05% BSA |
Preservative |
0.05% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Protein A purified |
Alternate Names for IMP Dehydrogenase 2/IMPDH2 Antibody
Background
IMPDH, inosine monophosphate dehydrogenase, has been demonstrated to mediate negative regulation of Toll-like receptor 2 activity via the NF-kB signaling pathway (1). IMPDH upregulates phosphatase activity of SHP-1 which then goes on to inactivate PI3-k. The central function of IMPDH in the regulation of guanosine nucleotide pathways- conversion of IMP- inosine monophosphate to XMP-xanthosine monophosphate is a critical controlling step in de novo synthesis of guanosine nucleotides in T and B lymphocytes affecting proliferation (2). Because of this, IMPDH specific detection and control has made it a target for immunosuppressive, anti-cancer, anti-parasitic, or anti-viral therapy (3). Monitoring IMPDH or IMPDH2 activity as a biomarker for mycophenolic acid-induced immunosuppression in renal transplants is one such use of IMPDH or IMPDH2 specific probes (4).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Secondary Antibodies
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