Topoisomerase I Antibody - BSA Free

Topoisomerases are nuclear enzymes involved in a variety of cellular activities such as chromosome condensation, DNA replication, transcription, recombination and segregation at mitosis. Human topoisomerase I is a 100kD protein capable of relaxing positively and negatively supercoiled DNA by performing a transient single stranded nick which is then religated at the end of the reaction. It has been shown that the enzyme is located in regions of the genome that are undergoing active RNA synthesis, where it probably reduces superhelical stresses in the DNA, enabling RNA polymerase to function properly. Both DNA topoisomerases I and II have been found to be targets of autoantibodies in the sera of patients with certain autoimmune diseases such as systemic lupus erythematosus and also of some anti tumor drugs and antibiotics. Elevated levels of DNA topoisomerase I, detected by transfer assays, have been demonstrated in colorectal tumors compared with normal colon mucosa as a result of increased transcription or mRNA stability.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC/IF, PLA, WB.

Showing Publication 1 - 1 of 1.

Publication using NBP1-90365	Applications	Species
Hu J, Lin SL, Schachner M A fragment of cell adhesion molecule L1 reduces amyloid-beta plaques in a mouse model of Alzheimer's disease Cell death & disease 2022-01-10 [PMID: 35013124] (WB, ICC/IF, PLA, Mouse)	WB, ICC/IF, PLA	Mouse

Array NBP1-90365

• Topoisomerase I Antibodies
• Topoisomerase I ELISA Kits
• Topoisomerase I Lysate
• Topoisomerase I Proteins