NUP98 Antibody

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-93325	Applications	Species
Blasius TL, Takao D, Verhey KJ NPHP proteins are binding partners of nucleoporins at the base of the primary cilium PLoS ONE 2019-09-25 [PMID: 31553752] (ICC/IF, Human)	ICC/IF	Human
McCloskey A, Ibarra A, Hetzer MW. Tpr regulates the total number of nuclear pore complexes per cell nucleus. Genes Dev. 2018-09-18 [PMID: 30228202] (ICC/IF, Human)	ICC/IF	Human
Lee SH, Singh I, Tisdale S et al. Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Nature 2018-08-27 [PMID: 30150773] (WB, Human)	WB	Human
Franks TM, Benner C, Narvaiza I et al. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev 2016-05-15 [PMID: 27198230] (WB)	WB

Array NB100-93325

• NUP98 Antibodies
• NUP98 Proteins