TOP2A Antibody

Topo II Alpha encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NBP1-86928	Applications	Species
Andersson S, Konrad A, Ashok N et al. Antibodies Biotinylated Using a Synthetic Z-domain from Protein A Provide Stringent In Situ Protein Detection. J Histochem Cytochem 2013-11-01 [PMID: 23920108]
Linden M, Segersten U, Runeson M et al. Tumour expression of bladder cancer-associated urinary proteins. BJU Int 2013-08-01 [PMID: 23470167]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Yongkang Yang	WB	Human	03/06/2021	View Summary Application Western Blot Sample Tested BREAST CANCER CELL LINES, Sample Amount: 40 ug Species Human Lot A115216

Array NBP1-86928

• TOP2A Antibodies
• TOP2A Lysate
• TOP2A Proteins