ABCG2/CD338 Antibody (3G8) - BSA Free

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: IHC-P, Immunocytochemistry/ Immunofluorescence, WB, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using NBP2-22124	Applications	Species
Fridman LB, Knerler S, Price AS et al. Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier bioRxiv 2023-08-02 [PMID: 37546800] (Western Blot, Immunocytochemistry/ Immunofluorescence)	Western Blot, Immunocytochemistry/ Immunofluorescence
Bhadwal P, Randhawa V, Vaiphei K et al. Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance Scientific reports 2022-10-29 [PMID: 36309544] (WB, Human) Details: Dilution used in WB 1:1000	WB	Human
Yamamoto S, Fukuhara H, Seki H Et Al. Predictors of therapeutic efficacy of 5-aminolevulinic acid-based photodynamic therapy in human prostate cancer Photodiagnosis and photodynamic therapy 2021-07-21 [PMID: 34303032] (IHC-P)	IHC-P
Huang R, Zhu L, Zhang Y XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way Cancer cell international 2020-09-04 [PMID: 32943985] (WB, Human)	WB	Human
Sridharan S, Robeson M, Bastihalli-Tukaramrao D, et al. Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness Front Oncol 2019-12-06 [PMID: 31867270] (WB, Human)	WB	Human
Erdogan S, Turkekul K, Dibirdik I et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway Biomed. Pharmacother. 2018-08-21 [PMID: 30142541] (WB, Human)	WB	Human
Agarwalla P, Mukherjee S, Sreedhar B, Banerjee R. Glucocorticoid receptor-mediated delivery of nano gold-withaferin conjugates for reversal of epithelial-to-mesenchymal transition and tumor regression. Nanomedicine (Lond) 2016-10-01 [PMID: 27622735]
Mondal SK, Jinka S, Pal K et al. Glucocorticoid Receptor-Targeted Liposomal Codelivery of Lipophilic Drug and Anti-Hsp90 Gene: Strategy to Induce Drug-Sensitivity, EMT-Reversal, and Reduced Malignancy in Aggressive Tumors. Mol. Pharm. 2016-07-05 [PMID: 27184196] (WB)	WB

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: KARTHIKEYAN THIRUGNANAM	ICC	Human	12/20/2024	View Summary Application Immunocytochemistry Sample Tested human brain microvascular endothelial cells Species Human Lot A-8
	1 reviewed by: Pauline Jeannot	ICC	Human	11/16/2023	View Summary Application Immunocytochemistry Sample Tested A2058 human melanoma cell line Species Human Lot A-6 Comments Comments ***Bio-Techne Response: Thank you for reviewing our product. We are sorry to hear that this product did not perform as expected. We have been in touch with the customer to resolve this issue according to our Product Guarantee and to the customer’s satisfaction.***

Array NBP2-22124

• ABCG2/CD338 Antibodies
• ABCG2/CD338 ELISA Kits