IKK gamma Antibody - BSA Free

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The IkappaB kinase (IKKalpha and IKKbeta) phosphorylates IkB and mediates NF-kappaB activation. A novel molecule in the IKK complex was recently identified and termed IKKgamma/NEMO/FIP3/IKKAP1. IKKgamma interacts with IKKbeta and is required for the activation of IKK complex and NF-kappaB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-kappaB activation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Flow Cytometry Control, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-76799	Applications	Species
Alameda Josefa P, Ramirez Angel, Garcia-Fernandez Rosa A et al. Premature aging and cancer development in transgenic mice lacking functional CYLD. Arteriosclerosis, Thrombosis, and Vascular Biology 2019-01-10 [PMID: 30631004] (WB, Mouse)	WB	Mouse
Sadaka C, Marloie-Provost MA, Soumelis V, Benaroch P. Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells. Blood. 2009-03-05 [PMID: 19015396] (Flow Cytometry Control) Details: Human pDC cells were pre-incubated with IMG-2000, Fig. 7.	Flow Cytometry Control

Array NBP1-76799

• IKK gamma Antibodies
• IKK gamma Inhibitor
• IKK gamma Lysates
• IKK gamma Proteins