TAK1 Antibody

TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). TAK1 is stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF-b activated kinase 1) MAPKKK in TGF-b signal transduction. TAB1-induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF-a activated endogenous TAK1, and the kinase-negative TAK1 acted as a dominant negative inhibitor against TNF-a-induced NF-kB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 2 of 2.

Publications using NB100-56363	Applications	Species
Sung Hsieh HH, Agarwal S, Cholok DJ et al. Coordinating Tissue Regeneration through TGF-b Activated Kinase 1 (TAK1) In-activation and Re-activation Stem Cells 2019-02-20 [PMID: 30786091] (IF/IHC, Mouse)	IF/IHC	Mouse
Liepelt A, Mossanen JC, Denecke B et al. Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation. RNA 2014-04-21 [PMID: 24751651] (WB, Mouse) Details: RAW264.7 and bone marrow-derived macrophages: IF (Figs 4A, 6A), WB (Fig 4B).	WB	Mouse

Array NB100-56363

• TAK1 Antibodies
• TAK1 Lysate
• TAK1 Proteins