IKK gamma Products

Description

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM]

Bioinformatics

Entrez	16151 Mouse 309295 Rat 8517 Human
Uniprot	AAH50612 Human AF074382 Human NP_001093326 Human NP_001093327 Human NP_003630 Human NP_034677 Mouse Q9Y6K9 Human
Product By Gene ID	8517
Alternate Names	FIP-3IP2 FIP3NF-kappa-B essential modifier Fip3p I-kappa-B kinase subunit gamma IkB kinase gamma subunit IkB kinase subunit gamma IkB kinase-associated protein 1 IKKAP1 IKKG IKK-gammaIPD2 incontinentia pigmenti inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Inhibitor of nuclear factor kappa-B kinase subunit gamma IP IP1 NEMOAMCBX1 NFkappaB essential modulator NF-kappa-B essential modulator

Research Areas for IKK gamma

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Immunology
Innate Immunity
Phospho-Specific

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Regulating Immune Response Pathways with IKK beta IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.

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