IKK gamma Antibody (72C627) [Biotin]

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 5 of 5.

Publications using NBP2-24816	Applications	Species
Siggs OM, Berger M, Krebs P et al. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Proc Natl Acad Sci U S A. 2010-02-16 [PMID: 20133626] (WB, Mouse) Details: NEMO (IMG-324A): WB (mouse macrophage lysates), Fig 2C.	WB	Mouse
Harikumar KB, Sung B, Pandey MK et al. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway Mol Pharmacol 2010-05-01 [PMID: 20103608] Details: This citation used the Alexa Fluor 488 version of this antibody.
Lamothe B, Campos AD, Webster WK et al. The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J Biol Chem. 2008-09-05 [PMID: 18617513]
Wunderlich FT, Luedde T, Singer S et al. Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proc Natl Acad Sci U S A. 2008-01-29 [PMID: 18216263]
Han HS, Karabiyikoglu M, Kelly S et al. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab. 2003-05-01 [PMID: 12771574] Details: Products cited for western blot in male Sprague-Dawley rats ischemic cortex, ischemic subcortex, contralateral cortex, and contralateral subcortex tissue. The rats were subject to mild and delayed hypothermia. 1. IKK-gamma (IMG-324A): Fig 4A & 4B. 2. IkB-

Array NBP2-24816

• IKK gamma Antibodies
• IKK gamma Inhibitor
• IKK gamma Lysates
• IKK gamma Proteins