IKK alpha Antibody (14A231) - BSA Free

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. In vitro, IKK1/a and IKK2/b can form homo- and heterodimers that can phosphorylate IkBs at the regulatory serine residues directly. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Targeted disruption of IKK1/a gene in mice results in skin and limb abnormalities and death of newborns.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Chemotaxis, Flow Cytometry Control, ICC/IF, IF/IHC, IHC-Fr, IHC-P, IP, WB.

Showing Publications 1 - 10 of 83. Show All 83 Publications. Collapse Publications.

Publications using NB100-56704	Applications	Species
Song NY, Li X, Ma B et al. IKK alpha-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines Proceedings of the National Academy of Sciences of the United States of America 2022-02-08 [PMID: 35121655] (IF/IHC, Chemotaxis, WB, Mouse)	IF/IHC, Chemotaxis, WB	Mouse
Wu Y, Ma L, Cai S et al. RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-kappa B hyper-activation and inflammation Signal Transduction and Targeted Therapy 2021-12-01 [PMID: 33895773]
Ni J, Guan C, Liu H et al. Ubc13 Promotes K63-Linked Polyubiquitination of NLRP3 to Activate Inflammasome Journal of immunology (Baltimore, Md. : 1950) 2021-04-23 [PMID: 33893171]
Shi D, Chen M, Liu L et al. Anti-influenza A virus mechanism of three representative compounds from Flos Trollii via TLRs signaling pathways J Ethnopharmacol 2020-01-28 [PMID: 32004628] (WB, Mouse)	WB	Mouse
Heringer JSP et al. The role of IKKalpha during diet-induced obesity and glucose intolerance in insulin sensitive tissues. The role of glycosylation during intestinal carcinogenesis Thesis. 2014-01-01 (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Garcia-Garcia V, Alameda J, Page A et al. IKKalpha Induces Epithelial-Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin International Journal of Molecular Sciences 2022-01-25 [PMID: 35163299] (ICC/IF)	ICC/IF
Page A, Ortega A, Alameda JP et al. IKK alpha Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization Comput Struct Biotechnol J. 2019-02-06 [PMID: 30867890] (WB, IHC-P, Mouse)	WB, IHC-P	Mouse
Liang S, Ma HY, Zhong Z et al. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice Gastroenterology 2019-03-01 [PMID: 30445007] (WB, Mouse)	WB	Mouse
Balkhi MY, Willette-Brown J, Wittmann G, Hu Y. IKKa deficiency disrupts the development of marginal zone and follicular B cells Genes Immun. 2018-05-08 [PMID: 29740197] (Mouse)		Mouse
Todoric J, Antonucci L, Di Caro G et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas Cancer Cell. 2017-11-07 [PMID: 29153842] (WB, Human)	WB	Human
Schwartz K, Bochkariov D. Novel chemiluminescent Western blot blocking and antibody incubation solution for enhanced antibody-antigen interaction and increased specificity Electrophoresis 2017-07-13 [PMID: 28704589] (WB)	WB
Zhu F, Willette-Brown J, Song NY et al. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017-04-12 [PMID: 28407484]
Diamanti MA, Gupta J, Bennecke M et al. IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 2017-02-01 [PMID: 28082356] (WB)	WB
Alameda JP, Navarro M, Ramirez A et al. IKKa regulates the stratification and differentiation of the epidermis: implications for skin cancer development. Oncotarget. 2016-11-22 [PMID: 27732959] (IHC-P, WB, Human)	IHC-P, WB	Human
Shintaku J, Peterson JM, Talbert EE et al. MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-B. Cell reports 1905-07-08 [PMID: 27705798] (Chemotaxis, WB, Mouse)	Chemotaxis, WB	Mouse
Alameda JP, Gaspar M, Ramirez A et al. Deciphering the role of nuclear and cytoplasmic IKKalpha in skin cancer. Oncotarget 2016-05-17 [PMID: 27121058] (IF/IHC, Human)	IF/IHC	Human
Fang X, Jeong JH, Long X et al. IKKalpha-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy. Cell Death Differ. [PMID: 27058318] Details: Citation using the Azide Free form of this antibody.
Vincendeau M, Hadian K, Messias AC et al. Inhibition of Canonical NF-kB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Sci Rep. 2016-01-07 [PMID: 26740240] (WB, Mouse)	WB	Mouse
Remouchamps C, Dejardin E. Methods to Assess the Activation of the Alternative (Noncanonical) NF-kB Pathway by Non-death TNF Receptors Methods Mol. Biol. 2015-03-04 [PMID: 25736746]
Mihalas AB, Meffert MK. IKK Kinase Assay for Assessment of Canonical NF-kB Activation in Neurons Methods Mol. Biol. 2015-03-04 [PMID: 25736744]
Richardson RJ, Hammond NL, Coulombe PA et al. Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin. Invest. 2014-08-18 [PMID: 25133425] (IHC-Fr, Mouse) Details: IKK alpha antibody used for IHC-Fr on mouse embryos - 4% paraformaldehyde-fixation, HIER with 10 mM citrate buffer at 96C for 10 minutes, primary used at 1:100 dilution with 4C ON incubation (Figure 3).	IHC-Fr	Mouse
Buhrmann C, Busch F, Shayan P, Shakibaei M. Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells. J. Biol. Chem. 2014-06-24 [PMID: 24962570] (IP, WB, Human) Details: IP & WB: Fig 5C, Primary chondrocytes and mesenchymal stem cells. The IKK alpha mAb immunoprecipitated an active immune complex as shown by an immune complex assay (Fig 5C).	IP, WB	Human
Gray CM, McCorkell KA, Chunduru SK et al. Negative feedback regulation of NF-kB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis. Biochem. Biophys. Res. Commun. 2014-06-02 [PMID: 24942881] (WB, Mouse) Details: Figs 1, 2D: mouse embryo fibroblasts (MEFs) from IKK alpha WT type and knockout (KO) mice. The specificity of the IKK alpha mAb validated in IKK alpha KO MEFs by WB (Fig 1).	WB	Mouse
Ikkalpha Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Goktuna SI, Canli O, Bollrath J et al. Cell Rep [PMID: 24882009] (WB, Mouse)	WB	Mouse
Das U, Manna K, Sinha M et al. Role of ferulic Acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS One 2014-05-24 [PMID: 24854039] (WB, Mouse)	WB	Mouse
Pradhan N, Pratheek BM, Garai A et al. Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell Biol. Int. 2014-05-07 [PMID: 24804954] (Flow Cytometry Control, Human) Details: Mouse splenocytes, human PBMC, Jurkat, EL4: Fig 5. GADPH was detected at ~36 kDa.	Flow Cytometry Control	Human
Gray CM, Remouchamps C, McCorkell KA et al. Noncanonical NF-kB Signaling Is Limited by Classical NF-kB Activity. Sci Signal. 2014-02-05 [PMID: 24497610] (WB, IP, Mouse) Details: Mouse embryo fibroblasts (MEFs) retrovirally transduced with various constructs, Figs 1-7.	WB, IP	Mouse
Ren T, Takahashi Y, Liu X et al. HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains. Oncogene 2013-12-23 [PMID: 24362528] (WB, Human)	WB	Human
Bimonte S, Barbieri A, Palma G et al. Curcumin inhibits tumor growth and angiogenesis in an orthotopic Mouse model of human pancreatic cancer. Biomed Res Int 2013-01-01 [PMID: 24324975] (WB, Human) Details: PaCa-2 (human pancreatic cell line) orthotopic mouse model of human pancreatic cancer, Fig 3C.	WB	Human
Mihalas AB, Araki Y, Huganir RL et al. Opposing Action of Nuclear Factor kB and Polo-like Kinases Determines a Homeostatic End Point for Excitatory Synaptic Adaptation. J Neurosci 2013-10-16 [PMID: 24133254] (IP, Mouse, Human)	IP	Mouse, Human
Schwitalla Sarah, Fingerle Alexander A, Cammareri Patrizia et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013-01-17 [PMID: 23273993] (WB)	WB
Cui J, Li Y, Zhu L et al. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat Immunol. 2012-03-04 [PMID: 22388039]
Bakkar N, Ladner K, Canan BD et al. IKKa and alternative NF-kB regulate PGC-1B to promote oxidative muscle metabolism. J Cell Biol. 2012-02-20 [PMID: 22351927]
Delhase M, Kim SY, Lee H et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012-01-24 [PMID: 22203995]
Phromnoi K, Reuter S, Sung B et al. A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IkB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. Mol Pharmacol. 2011-02-01 [PMID: 20930110] (WB, Human) Details: KBM-5 cells: 1. FLIP (IMG-116-1, -2): WB (Fig 4A) 2. IKKb/IKK2 (IMG-129A): IP Kinase Assay (Fig 2D), IP/WB (Fig 2D). Note, the antibody IP'd an active kinase. The antibody co'IP'd IKKa. 3. IKKa (IMG-136a): WB (Figs 2C, 2D). Note Fig 2D was generated with an IP (IKKb, IMG-129A)/WB (IKKa, IMG-136a) assay. Note: The KBM-5 (human chronic myeloid leukemia) cells were incubated with PMF then treated with TNF-alpha, Figs 2C, 2D, 4A.	WB	Human
Harikumar KB, Sung B, Pandey MK et al. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway Mol Pharmacol 2010-05-01 [PMID: 20103608] (WB) Details: This citation used the Alexa Fluor 488 version of this antibody.	WB
Hao L, Rizzo P, Osipo C et al. Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene. 2010-01-14 [PMID: 19838210]
Huang J, Ren T, Guan H et al. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J Biol Chem. 2009-03-06 [PMID: 19129196] (WB, Human) Details: Antibodies cited: 1. IMX-5142 (IkBa- Sera): WB (human T cell lines), Fig. 1B. 2. IMG-136A (Ikka/Ikk1): WB (human T cell lines), Figs. 1E,D,G; 2A; 3D,E,F,G; 4B,F; 6C,D; 7C,D,G. 3. IMG-129A (Ikkb/Ikk2): WB (human T cell lines), Figs. 1E,D,G; 2A; 3D,E,F,G; 4	WB	Human
Vallabhapurapu Sivakumar, Matsuzawa Atsushi, Zhang Weizhou et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008-12-01 [PMID: 18997792]
Kunnumakkara AB, Ichikawa H, Anand P et al. Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis. Mol Cancer Ther. 2008-10-01 [PMID: 18852134] (WB, Human) Details: IKK-alpha/IKK1 (IMG-136A): WB (human KMB-5 cells), Fig. 2C. 2. IKKb/IKK2 (IMG-129A): WB (human KMB-5 cells), Fig. 2C.	WB	Human
Eckmann L, Nebelsiek T, Fingerle AA et al. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008-09-30 [PMID: 18815378] (WB, Mouse) Details: WB (mouse colon cells), Fig. 4A.	WB	Mouse
Otipoby KL, Sasaki Y, Schmidt-Supprian M et al. BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. Proc Natl Acad Sci U S A. 2008-08-26 [PMID: 18713867] (WB, Mouse) Details: WB (mouse splenic B cells), Fig. 1B.	WB	Mouse
Pandey MK, Sung B, Kunnumakkara AB et al. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res. 2008-07-01 [PMID: 18593939] (WB, Human) Details: IMG-136A (IKKa/IKK1): WB (human multiple myeloma U266 cells), Fig. 3A, C. 2. IMG-129A (IKKb/IKK1): WB (human multiple myeloma U266 cells), Fig. 3A, C.	WB	Human
Kasinski AL, Du Y, Thomas SL et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol. 2008-09-01 [PMID: 18577686] (IP, Human) Details: Antibodies cited: 1. Ikka/Ikk1 (IMG-136A): IP (human A549 cells), immunoprecipitated cytoplasmic extracts were used for Ikk kinase assays. 2. Ikkb/Ikk2 (IMG-129A):WB (human A549 cells), Fig. 5a; 6a,b.	IP	Human
Beraza N, Ludde T, Assmus U et al. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology. 2007-06-01 [PMID: 17570222] (WB, Mouse) Details: Products cited: 1. IMG-129A (Ikkb/Ikk2): IP (mouse liver proteins), Fig. 1E; Tab. 1. 2. IMG-136A (Ikka/Ikk1): WB (mouse live proteins), Fig. 1E.	WB	Mouse
Burckstummer T, Bennett KL, Preradovic A et al. An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells. Nat Methods. 2006-12-01 [PMID: 17060908]
Richardson RJ, Dixon J, Malhotra S et al. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet. 2006-11-01 [PMID: 17041603]
Jackson-Bernitsas DG, Ichikawa H, Takada Y et al. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007-03-01 [PMID: 16953224]
Chae S, Eckmann L, Miyamoto Y et al. Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006-07-15 [PMID: 16818780]
Sethi G, Ahn KS, Sandur SK et al. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006-08-18 [PMID: 16785236]
Vacca Alessandra, Felli Maria Pia, Palermo Rocco et al. Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J. 2006-03-08 [PMID: 16498412]
Ichikawa H, Aggarwal BB. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006-01-15 [PMID: 16428513]
Vinolo E, Sebban H, Chaffotte A et al. A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation. J Biol Chem. 2006-03-10 [PMID: 16379012]
Shishodia S, Amin HM, Lai R et al. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005-09-01 [PMID: 16023083]
Ichikawa H, Takada Y, Murakami A, Aggarwal BB. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005-06-01 [PMID: 15905586]
Ruocco MG, Maeda S, Park JM et al. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005-05-16 [PMID: 15897281]
Nishio M, Endo T, Tsukada N et al. Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha. Blood. 2005-08-01 [PMID: 15860672]
Nonaka M, Horie R, Itoh K et al. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005-06-02 [PMID: 15782119]
Panopoulos A, Harraz M, Engelhardt JF, Zandi E. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005-01-28 [PMID: 15550384]
Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004-11-05 [PMID: 15322087]
Shishodia S, Koul D, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 2004-08-01 [PMID: 15265936]
Takada Y, Fang X, Jamaluddin MS et al. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem. 2004-09-17 [PMID: 15252041]
Chandrasekar B, Vemula K, Surabhi RM et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem. 2004-05-07 [PMID: 14960579] (WB, Human) Details: WB (human cardiac microvascular endothelial cells), Fig. 2G.	WB	Human
Takada Y, Singh S, Aggarwal BB. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004-04-09 [PMID: 14711835] (WB, Human)	WB	Human
Takada Y, Aggarwal BB. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem. 2004-02-06 [PMID: 14630924]
Saito N, Courtois G, Chiba A et al. Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines. J Biol Chem. 2003-11-21 [PMID: 12968033]
Shishodia S, Majumdar S, Banerjee S et al. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res. 2003-08-01 [PMID: 12907607]
Chen LW, Egan L, Li ZW et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003-05-01 [PMID: 12692538]
Majumdar S, Aggarwal BB. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene. 2003-02-27 [PMID: 12606947]
Greten Florian R, Weber Christoph K, Greten Tim F et al. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology. 2002-12-01 [PMID: 12454861] (Mouse)		Mouse
Ashikawa K, Majumdar S, Banerjee S et al. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol. 2002-12-01 [PMID: 12444159]
Chinanonwait N, Miura H, Yamamoto N, Yamaoka S. A recessive mutant cell line with a constitutive IkappaB kinase activity. FEBS Lett. 2002-11-20 [PMID: 12435610] (WB) Details: WB (Tk26 cells), Fig. 2c WB (Tk26 and M319-5 cells treated with cycloheximide), Fig. 3c WB (B5, Tk26, and hybrid Tk26--Rat-1 cells), Fig. 6b	WB
Dejardin E, Droin NM, Delhase M et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002-10-01 [PMID: 12387745]
Makris C, Roberts JL, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002-09-01 [PMID: 12192055]
Anto RJ, Mukhopadhyay A, Shishodia S et al. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002-09-01 [PMID: 12189195]
Majumdar S, Lamothe B, Aggarwal BB. Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J Immunol. 2002-03-15 [PMID: 11884428]
Agou F, Ye F, Goffinont S et al. NEMO trimerizes through its coiled-coil C-terminal domain. J Biol Chem. 2002-05-17 [PMID: 11877453]
Cao Y, Bonizzi G, Seagroves TN et al. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001-12-14 [PMID: 11747812]
Majumdar S, Aggarwal BB. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J Immunol. 2001-09-01 [PMID: 11509639]
Miller BS, Zandi E. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001-09-28 [PMID: 11470787]
Koul D, Yao Y, Abbruzzese JL et al. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. J Biol Chem. 2001-04-06 [PMID: 11278366]
Manna SK, Mukhopadhyay A, Aggarwal BB. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000-11-15 [PMID: 11067959]
Manna SK, Mukhopadhyay A, Aggarwal BB. IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. J Immunol. 2000-11-01 [PMID: 11046018]
Show All 83 Publications. Collapse Publications.

Array NB100-56704

• IKK alpha Antibodies
• IKK alpha Lysate
• IKK alpha Proteins