Human Total PDGF R beta DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 2 of 2.

Publications using DYC385-2	Applications	Species
Aderhold C, Faber A, Grobschmidt G, Chakraborty A, Bockmayer A, Umbreit C, Birk R, Stern-Straeter J, Hormann K, Schultz J Small molecule-based chemotherapeutic approach in p16-positive and -negative HNSCC in vitro. Anticancer Res, 2013-12-01;33(12):5385-93. 2013-12-01 [PMID: 24324073] (Human)		Human
Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol., 2011-01-18;31(6):1174-85. 2011-01-18 [PMID: 21245381] (Human)		Human

Array DYC385-2

• PDGF R beta Antibodies
• PDGF R beta Antibody Pair
• PDGF R beta Lysate
• PDGF R beta Protein
• PDGF R beta Proteins and Enzymes
• PDGF R beta ELISAs