PDGF-B Antibody

PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 2 of 2.

Publications using NBP1-58279	Applications	Species
Yao F, Luo Y, Liu YC et al. Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFR? pathway in spinal cord injury Inflammation and Regeneration 2022-09-26 [PMID: 36163271]
Li Z, Yu S, Liu Y et al. SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFR beta pathway Journal of neuroinflammation 2022-04-16 [PMID: 35429978] (IF/IHC, Mouse)	IF/IHC	Mouse

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: KARTHIKEYAN THIRUGNANAM	ICC	Human	01/23/2024	View Summary Application Immunocytochemistry Sample Tested Brain microvascular endothelial cells,HUman brain microvascular endothelial cells Species Human Lot QC56462-160608 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.***
	5 reviewed by: Verified Customer	KD	Human	03/22/2023	View Summary Application Knockdown Validated Sample Tested 20 ug whole cell lysate Species Human Lot QC56462-160608 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** Knockdown was performed with PDGF-B human siRNA using 20 nM concentration using transfection reagent. Primary antibody dilution - 1:500.

Array NBP1-58279

• PDGF-B Antibodies
• PDGF-B ELISA Kits
• PDGF-B Lysate
• PDGF-B Proteins